401486 Sigma-AldrichIKK Inhibitor VII - CAS 873225-46-8 - Calbiochem
IKK Inhibitor VII, CAS 873225-46-8, is a cell-permeable, potent, selective, and ATP-competitive inhibitor of IKK (IC50 = 40, 70, and 200 nM for IKK-2, IKK complex & IKK-1, respectively).
More>> IKK Inhibitor VII, CAS 873225-46-8, is a cell-permeable, potent, selective, and ATP-competitive inhibitor of IKK (IC50 = 40, 70, and 200 nM for IKK-2, IKK complex & IKK-1, respectively). Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: IKK 16
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Overview
Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 873225-46-8 | C₂₈H₂₉N₅OS |
Products
| Catalogue Number | Packaging | Qty/Pack | |
|---|---|---|---|
| 401486-1MGCN | Glass bottle | 1 mg |
| Description | |
|---|---|
| Overview | A cell-permeable benzamido-pyrimidine compound that acts as a potent, selective, and ATP-competitive inhibitor of IKK (IC50 = 40 nM, 70 nM, and 200 nM for IKK-2, IKK complex, and IKK-1, respectively). Inhibits cellular IκBα degradation and NF-κB-mediated gene expression in vitro in HUVEC cells and has been shown to exhibit excellent in vivo efficacy both in mice and rats. Also available as a 10 mM solution in DMSO (Cat. No. 505378). |
| Catalogue Number | 401486 |
| Brand Family | Calbiochem® |
| Synonyms | IKK 16 |
| References | |
|---|---|
| References | Waelchli, R., et al. 2006. Bioorg. Med. Chem. Lett. 16, 108. |
| Product Information | |
|---|---|
| CAS number | 873225-46-8 |
| ATP Competitive | Y |
| Form | Pale yellow solid |
| Hill Formula | C₂₈H₂₉N₅OS |
| Chemical formula | C₂₈H₂₉N₅OS |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Primary Target | IKK |
| Primary Target IC<sub>50</sub> | 40 nM, 70 nM, and 200 nM for IKK-2, IKK complex, and IKK-1, respectively |
| Purity | ≥97% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Safety Information | |
|---|---|
| R Phrase | R: 22 Harmful if swallowed. |
| S Phrase | S: 22-24/25 Do not breathe dust. Avoid contact with skin and eyes. |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Global Trade Item Number | |
|---|---|
| Catalogue Number | GTIN |
| 401486-1MGCN | 04055977212013 |