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382110 Histone Acetyltransferase Inhibitor II - CAS 932749-62-7 - Calbiochem

The Histone Acetyltransferase Inhibitor II, also referenced under CAS 932749-62-7, controls the biological activity of Histone Acetyltransferase. This small molecule/inhibitor is primarily used for Cell Structure applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2,6-bis-(3-Bromo-4-hydroxybenzylidene)cyclohexanone, HAT Inhibitor II, p300/CBP Inhibitor II, GCN5 Inhibitor I

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382110
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
932749-62-7C₂₀H₁₆Br₂O₃

Products

Catalogue NumberPackaging Qty/Pack
382110-10MGCN Plastic ampoule 10 mg
Description
OverviewA cell-permeable bis-arylidene cyclohexanone compound that acts as a p300/CBP-selective histone acetyltransferase inhibitor (IC50 = 5 µM), while it affects GCN5 and PCAF only at much higher concentrations (30% and 0% inhibition, respectively, at 5 µM inhibitor concentration). Shown to decrease histone H3 acetylation (IC50 ≤ 40 µM) and induce chromatin condensation in HeLa cells.
Catalogue Number382110
Brand Family Calbiochem®
Synonyms2,6-bis-(3-Bromo-4-hydroxybenzylidene)cyclohexanone, HAT Inhibitor II, p300/CBP Inhibitor II, GCN5 Inhibitor I
References
ReferencesCosti, R., et al. 2007. J. Med. Chem. 50, 1973.
Product Information
CAS number932749-62-7
FormYellow solid
Hill FormulaC₂₀H₁₆Br₂O₃
Chemical formulaC₂₀H₁₆Br₂O₃
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
382110-10MGCN 04055977213096

Documentation

Histone Acetyltransferase Inhibitor II - CAS 932749-62-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Histone Acetyltransferase Inhibitor II - CAS 932749-62-7 - Calbiochem Certificates of Analysis

TitleLot Number
382110

References

Reference overview
Costi, R., et al. 2007. J. Med. Chem. 50, 1973.

Brochure

Title
Pathways and Biomarkers of Toll-like Receptor (TLR) Signaling
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-April-2011 RFH
Synonyms2,6-bis-(3-Bromo-4-hydroxybenzylidene)cyclohexanone, HAT Inhibitor II, p300/CBP Inhibitor II, GCN5 Inhibitor I
DescriptionA cell-permeable bis-arylidene cyclohexanone compound that acts as a p300/CBP-selective histone acetyltransferase inhibitor (IC50 = 5 µM), while it affects GCN5 and PCAF only at much higher concentrations (30% and 0% inhibition, respectively, at 5 µM inhibitor concentration). Shown to decrease histone H3 acetylation (IC50 ≤40 µM) and induce chromatin condensation in HeLa cells.
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number932749-62-7
Chemical formulaC₂₀H₁₆Br₂O₃
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (25 mg/ml) or Ethanol (10 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month.
Toxicity Standard Handling
ReferencesCosti, R., et al. 2007. J. Med. Chem. 50, 1973.