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531067 HSP70 Inhibitor, PES-Cl - CAS 1321611-23-7 - Calbiochem

Directly binds to HSP70 and disrupts its interaction with client proteins..

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Heat Shock Protein 70 Inhibitor

Primary Target: HSP70
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1321611-23-7C₈H₆ClNO₂S

Products

Catalogue NumberPackaging Qty/Pack
5.31067.0001 Glass bottle 10 mg
Description
OverviewA cell-permeable chlorophenylethynylsulfonamide compound that binds directly to the substrate-binding domain of heat shock protein 70 (HSP70) and disrupts its interaction with client proteins. Impairs the activity of the anaphase promoting complex/cyclosome (APC/C) in cell-free extracts. Arrests cell cycle at G2/M phase and preferentially induces genomic instability in cancer cells (IC50 = 2 to 5 µM in melanoma cell lines). Exhibits much reduced toxicity in non-transformed cells (IC50 >100 µM in primary melanocytes). Induces apoptosis and inhibits autophagy as evidenced by increased p62SQSTM1 and LC3 accumulation. Also, shown to extend life in murine models of pre-B cell lymphoma.

Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number531067
Brand Family Calbiochem®
SynonymsHeat Shock Protein 70 Inhibitor
References
ReferencesBalaburski, G., et al. 2013. Mol. Cancer Res. 11, 1.
Budina-Kolomets, A. et al. 2013. Cancer Biol. Ther. 15, 194.
Product Information
CAS number1321611-23-7
FormWhite powder
Hill FormulaC₈H₆ClNO₂S
Chemical formulaC₈H₆ClNO₂S
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary TargetHSP70
Primary Target IC<sub>50</sub>2-5 µ
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
5.31067.0001 04055977242553

Documentation

HSP70 Inhibitor, PES-Cl - CAS 1321611-23-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Balaburski, G., et al. 2013. Mol. Cancer Res. 11, 1.
Budina-Kolomets, A. et al. 2013. Cancer Biol. Ther. 15, 194.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision29-August-2014 JSW
SynonymsHeat Shock Protein 70 Inhibitor
DescriptionA cell-permeable chlorophenylethynylsulfonamide compound that binds directly to the substrate-binding domain of heat shock protein 70 (HSP70) and disrupts its interaction with client proteins. Impairs the activity of the anaphase promoting complex/cyclosome (APC/C) in cell-free extracts. Arrests cell cycle at G2/M phase and preferentially induces genomic instability in cancer cells (IC50 = 2 to 5 µM in melanoma cell lines). Exhibits much reduced toxicity in non-transformed cells (IC50 >100 µM in primary melanocytes). Induces apoptosis and inhibits autophagy as evidenced by increased p62SQSTM1 and LC3 accumulation. Also, shown to extend life in murine models of pre-B cell lymphoma.
FormWhite powder
Intert gas (Yes/No) Packaged under inert gas
CAS number1321611-23-7
Chemical formulaC₈H₆ClNO₂S
Purity≥98% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesBalaburski, G., et al. 2013. Mol. Cancer Res. 11, 1.
Budina-Kolomets, A. et al. 2013. Cancer Biol. Ther. 15, 194.