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361515 Glycogen Phosphorylase Inhibitor - CAS 648926-15-2 - Calbiochem

The Glycogen Phosphorylase Inhibitor, also referenced under CAS 648926-15-2, controls the biological activity of Glycogen Phosphorylase.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1-(3-(3-(2-Chloro-4,5-difluorobenzoyl)ureido)-4-methoxyphenyl)-3-methylurea

Primary Target: Glycogen phosphorylase
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
648926-15-2C₁₇H₁₅ClF₂N₄O₄

Products

Catalogue NumberPackaging Qty/Pack
361515-1MGCN Plastic ampoule 1 mg
361515-5MGCN Glass bottle 5 mg
Description
OverviewA cell-permeable urea compound that acts as a potent and AMP-competitive inhibitor of glycogen phosphorylase (GP; IC50 = 53 nM). Shown to inhibit glucagon-induced glyocgenolysis both in hepatocytes (IC50 = 380 nM) in vitro and in rats (5 mg/kg, iv) in vivo.
Catalogue Number361515
Brand Family Calbiochem®
Synonyms1-(3-(3-(2-Chloro-4,5-difluorobenzoyl)ureido)-4-methoxyphenyl)-3-methylurea
References
ReferencesKlabunde, T., et al. 2005. J. Med. Chem. 48, 6178
Product Information
CAS number648926-15-2
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₇H₁₅ClF₂N₄O₄
Chemical formulaC₁₇H₁₅ClF₂N₄O₄
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetGlycogen phosphorylase
Primary Target IC<sub>50</sub>53 nM against glycogen phosphorylase
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
361515-1MGCN 04055977192902
361515-5MGCN 04055977192919

Documentation

Glycogen Phosphorylase Inhibitor - CAS 648926-15-2 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Glycogen Phosphorylase Inhibitor - CAS 648926-15-2 - Calbiochem Certificates of Analysis

TitleLot Number
361515

References

Reference overview
Klabunde, T., et al. 2005. J. Med. Chem. 48, 6178
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision01-July-2008 RFH
Synonyms1-(3-(3-(2-Chloro-4,5-difluorobenzoyl)ureido)-4-methoxyphenyl)-3-methylurea
DescriptionA cell-permeable urea compound that acts as a potent and AMP-competitive inhibitor of glycogen phosphorylase (GP; IC50 = 53 nM). Shown to inhibit glucagon-induced glyocgenolysis both in hepatocytes (IC50 = 380 nM) in vitro and in rats (5 mg/kg, iv) in vivo.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number648926-15-2
Chemical formulaC₁₇H₁₅ClF₂N₄O₄
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (25 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Irritant
ReferencesKlabunde, T., et al. 2005. J. Med. Chem. 48, 6178