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538285 Glucosylceramide Synthase Inhibitor, Genz-123346 - CAS 491833-30-8 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (1R,2R)-nonanoic acid[2-(2ʹ,3ʹ-dihydro-benzo [1, 4] dioxin-6ʹ-yl)-2-hydroxy-1-pyrrolidin-1-ylmethyl-ethyl]-amide, GL1 synthase Inhibitor, Genz-123346, Genz123346

Primary Target: glucosylceramide synthase
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
491833-30-8C₂₄H₃₈N₂O₄

Products

Catalogue NumberPackaging Qty/Pack
5.38285.0001 Glass bottle 10 mg
Description
OverviewA cell-permeable, orally bioavailable fatty acid amide derivative that acts as a highly potent and specific inhibitor of Glucosylceramide Synthase (GL1 synthase; IC50 = 14 nM for ganglioside GM1 inhibition). Does not affect the activities of other related glycosidase, such as 1-O-acylceramide synthase, a-glucosidase, and glucocerebrosidase in any significant manner. Shown to improve glucose tolerance, improve insulin sensitivity, and normalize hemoglobin A1C levels in Zucker diabetic fatty rats (75 mg/kg/day, p.o. for 6 weeks). Also acts as an inhibitor of GlcCer synthase and blocks the conversion of ceramide to GlcCer in murine models that are orthologous to human autosomal dominant polycystic kidney disease and nephronophthisis. Diminishes Akt-mTOR signaling by reducing phosphorylation of Akt and ribosomal S6 kinase in HEK293T cells without affecting their total levels.

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
Catalogue Number538285
Brand Family Calbiochem®
Synonyms(1R,2R)-nonanoic acid[2-(2ʹ,3ʹ-dihydro-benzo [1, 4] dioxin-6ʹ-yl)-2-hydroxy-1-pyrrolidin-1-ylmethyl-ethyl]-amide, GL1 synthase Inhibitor, Genz-123346, Genz123346
References
ReferencesShen, W., et al. 2014. J. Neurochem. 129, 884.
Natoli, T.A., et al. 2010. Nat. Med. 16, 788.
Zhao, H., et al. 2007. Diabetes. 56, 1210.
Product Information
CAS number491833-30-8
FormWhite to off-white solid
Hill FormulaC₂₄H₃₈N₂O₄
Chemical formulaC₂₄H₃₈N₂O₄
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary Targetglucosylceramide synthase
Primary Target IC<sub>50</sub>14 nM for ganglioside GM1 suppression
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient, Blue Ice or Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
5.38285.0001 04054839119569

Documentation

Glucosylceramide Synthase Inhibitor, Genz-123346 - CAS 491833-30-8 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Shen, W., et al. 2014. J. Neurochem. 129, 884.
Natoli, T.A., et al. 2010. Nat. Med. 16, 788.
Zhao, H., et al. 2007. Diabetes. 56, 1210.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision28-July-2017 JSW
Synonyms(1R,2R)-nonanoic acid[2-(2ʹ,3ʹ-dihydro-benzo [1, 4] dioxin-6ʹ-yl)-2-hydroxy-1-pyrrolidin-1-ylmethyl-ethyl]-amide, GL1 synthase Inhibitor, Genz-123346, Genz123346
DescriptionA cell-permeable, orally bioavailable fatty acid amide derivative that acts as a highly potent and specific inhibitor of Glucosylceramide Synthase (GL1 synthase; IC50 = 14 nM for ganglioside GM1 inhibition). Does not affect the activities of other related glycosidase, such as 1-O-acylceramide synthase, a-glucosidase, and glucocerebrosidase in any significant manner. Shown to improve glucose tolerance, improve insulin sensitivity, and normalize hemoglobin A1C levels in Zucker diabetic fatty rats (75 mg/kg/day, p.o. for 6 weeks). Also acts as an inhibitor of GlcCer synthase and blocks the conversion of ceramide to GlcCer in murine models that are orthologous to human autosomal dominant polycystic kidney disease and nephronophthisis. Diminishes Akt-mTOR signaling by reducing phosphorylation of Akt and ribosomal S6 kinase in HEK293T cells without affecting their total levels.
FormWhite to off-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number491833-30-8
Chemical formulaC₂₄H₃₈N₂O₄
Purity≥98% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesShen, W., et al. 2014. J. Neurochem. 129, 884.
Natoli, T.A., et al. 2010. Nat. Med. 16, 788.
Zhao, H., et al. 2007. Diabetes. 56, 1210.