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344152 FPT Inhibitor II - Calbiochem

The FPT Inhibitor II controls the biological activity of FPT. This small molecule/inhibitor is primarily used for Cancer applications.

FPT Inhibitor II - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (E,E)-2-[2-Oxo-2-[[(3,7,11-trimethyl-2,6,10-dodecatrienyl)oxy]amino]ethyl]phosphonic Acid, 2Na

Primary Target: Farnesyltransferase (Ftase)
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₇H₂₈NO₅P • 2Na

Products

Catalogue NumberPackaging Qty/Pack
344152-1MGCN Plastic ampoule 1 mg
Description
OverviewA cell permeable potent and selective inhibitor of farnesyltransferase (FTase; IC50 = 75 nM). Also inhibits Ras farnesylation in whole cells by ~90% at 25-250 µM. Resistant to cleavage by phosphorylation.

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
Catalogue Number344152
Brand Family Calbiochem®
Synonyms(E,E)-2-[2-Oxo-2-[[(3,7,11-trimethyl-2,6,10-dodecatrienyl)oxy]amino]ethyl]phosphonic Acid, 2Na
References
ReferencesManne, V., et al. 1995. Drug Development Res. 34, 121.
Product Information
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₇H₂₈NO₅P • 2Na
Chemical formulaC₁₇H₂₈NO₅P • 2Na
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetFarnesyltransferase (Ftase)
Primary Target IC<sub>50</sub>75 nM against Ftase
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
344152-1MGCN 04055977215267

Documentation

FPT Inhibitor II - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

FPT Inhibitor II - Calbiochem Certificates of Analysis

TitleLot Number
344152

References

Reference overview
Manne, V., et al. 1995. Drug Development Res. 34, 121.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision23-March-2018 JSW
Synonyms(E,E)-2-[2-Oxo-2-[[(3,7,11-trimethyl-2,6,10-dodecatrienyl)oxy]amino]ethyl]phosphonic Acid, 2Na
DescriptionA highly selective and potent inhibitor of Ras farnesyltransferase (IC50 = 75 nM). Inhibits geranylgeranyltransferase I (IC50 = 24 µM) and II (IC50 = 24 µM) at much higher concentrations. Also inhibits Ras farnesylation in whole cells by ~90% at 10-100 µg/ml (25-250 µM). Resistant to cleavage by phosphorylation.
FormWhite solid
Chemical formulaC₁₇H₂₈NO₅P • 2Na
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityH₂O (≥10 mg/ml)
Storage -20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
Toxicity Standard Handling
ReferencesManne, V., et al. 1995. Drug Development Res. 34, 121.