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341205 Etoposide - CAS 33419-42-0 - Calbiochem

Etoposide, CAS 33419-42-0, is cell-permeable inhibitor of topoisomerase II inhibitor (IC50 = 59.2 µM). Displays anti-tumor activity.

Etoposide - CAS 33419-42-0 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: VP-16

Primary Target: topoisomerase 2
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
33419-42-0C₂₉H₃₂O₁₃

Products

Catalogue NumberPackaging Qty/Pack
341205-25MGCN Plastic ampoule 25 mg
Description
OverviewA cell-permeable derivative of podophyllotoxin that acts as a topoisomerase II inhibitor (IC50 = 59.2 µM) has major activity against a number of tumors, including germ cell neoplasms, small cell lung cancer, and malignant lymphoma. Induces apoptosis in mouse thymocytes and in HL-60 human leukemia cells.
Catalogue Number341205
Brand Family Calbiochem®
SynonymsVP-16
References
ReferencesDe Lange, A.M., et al. 1995. J. Virol. 69, 2082.
Kaufman, S.H., et al. 1993. Cancer Res. 53, 3976.
Onishi, Y., et al. 1993. Biochim. Biophys. Acta 1175, 147.
Terada, T., et al. 1993. J. Med. Chem. 36, 1689.
Wazniak, A.J., et al. 1991. J. Clin. Oncol. 9, 70.
Einhorn, L.H., et al. 1988. J. Clin. Oncol. 6, 451.
Issel, B.F. 1982. Cancer Chemother. Pharmacol. 7, 73.
Product Information
CAS number33419-42-0
ATP CompetitiveN
FormWhite solid
Hill FormulaC₂₉H₃₂O₁₃
Chemical formulaC₂₉H₃₂O₁₃
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationEtoposide, CAS 33419-42-0, is cell-permeable inhibitor of topoisomerase II inhibitor (IC50 = 59.2 µM). Displays anti-tumor activity.
Biological Information
Primary Targettopoisomerase 2
Primary Target IC<sub>50</sub>59.2 µM inhibiting topoisomerase II
Purity>95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSKC0190000
Safety Information
R PhraseR: 22-45

Harmful if swallowed.
May cause cancer.
S PhraseS: 26-36/37/39-45-53

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Avoid exposure - obtain special instructions before use.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful & Carcinogenic / Teratogenic
Storage +15°C to +30°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
341205-25MGCN 04055977215434

Documentation

Etoposide - CAS 33419-42-0 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Etoposide - CAS 33419-42-0 - Calbiochem Certificates of Analysis

TitleLot Number
341205

References

Reference overview
De Lange, A.M., et al. 1995. J. Virol. 69, 2082.
Kaufman, S.H., et al. 1993. Cancer Res. 53, 3976.
Onishi, Y., et al. 1993. Biochim. Biophys. Acta 1175, 147.
Terada, T., et al. 1993. J. Med. Chem. 36, 1689.
Wazniak, A.J., et al. 1991. J. Clin. Oncol. 9, 70.
Einhorn, L.H., et al. 1988. J. Clin. Oncol. 6, 451.
Issel, B.F. 1982. Cancer Chemother. Pharmacol. 7, 73.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision30-October-2023 JSW
SynonymsVP-16
DescriptionA cell-permeable, topoisomerase II inhibitor (IC50 = 59.2 µM). A derivative of podophyllotoxin (Cat. No. 540040) that has major activity against a number of tumors, including germ cell neoplasms, small cell lung cancer, and malignant lymphoma. Induces apoptosis in mouse thymocytes and in HL-60 human leukemia cells.
FormWhite solid
CAS number33419-42-0
RTECSKC0190000
Chemical formulaC₂₉H₃₂O₁₃
Structure formulaStructure formula
Purity>95% by HPLC
SolubilityDMSO (25 mg/ml)
Storage Protect from light
+15°C to +30°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Harmful & Carcinogenic / Teratogenic
Merck USA index14, 3886
ReferencesDe Lange, A.M., et al. 1995. J. Virol. 69, 2082.
Kaufman, S.H., et al. 1993. Cancer Res. 53, 3976.
Onishi, Y., et al. 1993. Biochim. Biophys. Acta 1175, 147.
Terada, T., et al. 1993. J. Med. Chem. 36, 1689.
Wazniak, A.J., et al. 1991. J. Clin. Oncol. 9, 70.
Einhorn, L.H., et al. 1988. J. Clin. Oncol. 6, 451.
Issel, B.F. 1982. Cancer Chemother. Pharmacol. 7, 73.