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574215 D,L-Sulforaphane - CAS 4478-93-7 - Calbiochem

D,L-Sulforaphane, CAS 4478-93-7, is an anti-tumor agent that acts as a potent inducer of phase II detoxifying enzymes in mouse tissues and murine hepatoma cells in culture.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1-Isothiocyanato-4-(methylsulfinyl)butane, R,S-Sulforaphane

Primary Target: Potent inducer of phase II detoxifying enzymes in mouse tissues and murine hepatoma cells in culture
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574215
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
4478-93-7C₆H₁₁NOS₂

Products

Catalogue NumberPackaging Qty/Pack
574215-25MGCN Plastic ampoule 25 mg
Description
OverviewAn isothiocyanate isolated from broccoli that acts as a potent inducer of phase II detoxifying enzymes in mouse tissues and murine hepatoma cells in culture. It has been shown to be an effective agent in prevention of chemically-induced mammary tumors in rats. It also inhibits the phase I cytochrome P450 isoenzymes 2E1 and IA2 which have been associated with the activation of carcinogens. The induction of phase II enzymes is mediated by mitogen-activated protein kinase (MAPK) pathway.
Catalogue Number574215
Brand Family Calbiochem®
Synonyms1-Isothiocyanato-4-(methylsulfinyl)butane, R,S-Sulforaphane
References
ReferencesGamet-Payrastre, L., et al. 2000. Cancer Res. 60, 1426.
Yu, R., et al. 2000. J. Biol. Chem. 275, 2322.
Yu, R., et al. 1999. J. Biol. Chem. 274, 27545.
Barcelo, S., et al. 1998. Mutat. Res. 402, 111.
Maheo, K., et al. 1997. Cancer Res. 57, 3649.
Zhang, Y., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3147.
Zhang, Y., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 2399.
Product Information
CAS number4478-93-7
ATP CompetitiveN
FormSlight yellow liquid
Hill FormulaC₆H₁₁NOS₂
Chemical formulaC₆H₁₁NOS₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationD,L-Sulforaphane, CAS 4478-93-7, is an anti-tumor agent that acts as a potent inducer of phase II detoxifying enzymes in mouse tissues and murine hepatoma cells in culture.
Biological Information
Primary TargetPotent inducer of phase II detoxifying enzymes in mouse tissues and murine hepatoma cells in culture
Purity≥98% by UPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze DMSO stock solutions (-20°C) and ethanol stock solutions (-70°C). DMSO stock solutions are stable for up to 3 months at -20°C and ethanol stock solutions are stable for up to 3 months at -70°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
574215-25MGCN 04055977189568

Documentation

D,L-Sulforaphane - CAS 4478-93-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

D,L-Sulforaphane - CAS 4478-93-7 - Calbiochem Certificates of Analysis

TitleLot Number
574215

References

Reference overview
Gamet-Payrastre, L., et al. 2000. Cancer Res. 60, 1426.
Yu, R., et al. 2000. J. Biol. Chem. 275, 2322.
Yu, R., et al. 1999. J. Biol. Chem. 274, 27545.
Barcelo, S., et al. 1998. Mutat. Res. 402, 111.
Maheo, K., et al. 1997. Cancer Res. 57, 3649.
Zhang, Y., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3147.
Zhang, Y., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 2399.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision26-March-2008 JSW
Synonyms1-Isothiocyanato-4-(methylsulfinyl)butane, R,S-Sulforaphane
DescriptionAn isothiocyanate isolated from broccoli that acts as a potent inducer of phase II detoxifying enzymes in mouse tissues and murine hepatoma cells in culture. Shown to be an effective agent in prevention of chemically-induce mammary tumors in rats. Also shown to inhibit the phase I cytochrome P450 isoenzymes 2E1 and IA2 that have been associated with the activation of carcinogens. The induction of phase II enzymes is mediated by the mitogen-activated protein kinase (MAPK) pathway.
FormSlight yellow liquid
Intert gas (Yes/No) Packaged under inert gas
CAS number4478-93-7
Chemical formulaC₆H₁₁NOS₂
Structure formulaStructure formula
Purity≥98% by UPLC
SolubilityDMSO (20 mg/ml) or ethanol (10 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze DMSO stock solutions (-20°C) and ethanol stock solutions (-70°C). DMSO stock solutions are stable for up to 3 months at -20°C and ethanol stock solutions are stable for up to 3 months at -70°C.
Toxicity Standard Handling
ReferencesGamet-Payrastre, L., et al. 2000. Cancer Res. 60, 1426.
Yu, R., et al. 2000. J. Biol. Chem. 275, 2322.
Yu, R., et al. 1999. J. Biol. Chem. 274, 27545.
Barcelo, S., et al. 1998. Mutat. Res. 402, 111.
Maheo, K., et al. 1997. Cancer Res. 57, 3649.
Zhang, Y., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3147.
Zhang, Y., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 2399.