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309795 DIDS, Disodium Salt - CAS 53005-05-3 - Calbiochem

Binds covalently and irreversibly to the outer surface of human erythrocyte membranes.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4,4ʹ-Diisothiocyanostilbene-2,2ʹ-disulfonic Acid, 2Na

Primary Target: Cl- uptake
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
53005-05-3C₁₆H₈N₂O₆S₄ · 2Na

Products

Catalogue NumberPackaging Qty/Pack
309795-250MGCN Plastic ampoule 250 mg
Description
OverviewBinds covalently and irreversibly to the outer surface of human erythrocyte membranes. Inhibits ATP transport into endoplasmic reticulum vesicles. Anion transport inhibitor that inhibits Cl– uptake (IC50 = 150 nM) in neuroblastoma cells. Has anti-ulcerous properties.
Catalogue Number309795
Brand Family Calbiochem®
Synonyms4,4ʹ-Diisothiocyanostilbene-2,2ʹ-disulfonic Acid, 2Na
References
ReferencesBettendorff, L., et al. 1995. Biochem. Biophys. Res. Commun. 207, 375.
Horie, S., et al. 1993. Res. Commun. Chem. Pathol. Pharmacol. 79, 117.
Mayinger, P., and Meyer, D.I. 1993. EMBO J. 12, 659.
Catantchik, Z.I., and Rothstein, A. 1974. J. Membr. Biol. 15, 207.
Product Information
CAS number53005-05-3
ATP CompetitiveN
FormYellow solid
Hill FormulaC₁₆H₈N₂O₆S₄ · 2Na
Chemical formulaC₁₆H₈N₂O₆S₄ · 2Na
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCl- uptake
Primary Target IC<sub>50</sub>150 nM inhibiting Cl- uptake in neuroblastoma cells
Purity≥85% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage -20°C
Protect from Light Protect from light
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
309795-250MGCN 04055977216790

Documentation

DIDS, Disodium Salt - CAS 53005-05-3 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

DIDS, Disodium Salt - CAS 53005-05-3 - Calbiochem Certificates of Analysis

TitleLot Number
309795

References

Reference overview
Bettendorff, L., et al. 1995. Biochem. Biophys. Res. Commun. 207, 375.
Horie, S., et al. 1993. Res. Commun. Chem. Pathol. Pharmacol. 79, 117.
Mayinger, P., and Meyer, D.I. 1993. EMBO J. 12, 659.
Catantchik, Z.I., and Rothstein, A. 1974. J. Membr. Biol. 15, 207.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision01-February-2024 JSW
Synonyms4,4ʹ-Diisothiocyanostilbene-2,2ʹ-disulfonic Acid, 2Na
DescriptionBinds covalently and irreversibly to the outer surface of human erythrocyte membrane proteins. Inhibits ATP transport into the endoplasmic reticulum vesicles. Anion transport inhibitor that inhibits Cl- uptake (IC50 = 150 nM) in neuroblastoma cells. Has antiulcerous activity.
FormYellow solid
CAS number53005-05-3
Chemical formulaC₁₆H₈N₂O₆S₄ · 2Na
Structure formulaStructure formula
Purity≥85% by HPLC
SolubilityH₂O (0.5%)
Storage Protect from moisture
Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Toxicity Irritant
ReferencesBettendorff, L., et al. 1995. Biochem. Biophys. Res. Commun. 207, 375.
Horie, S., et al. 1993. Res. Commun. Chem. Pathol. Pharmacol. 79, 117.
Mayinger, P., and Meyer, D.I. 1993. EMBO J. 12, 659.
Catantchik, Z.I., and Rothstein, A. 1974. J. Membr. Biol. 15, 207.