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376650
Sigma-AldrichD-erythro-Sphingosine, N-Hexanoyl- - CAS 124753-97-5 - Calbiochem
Biologically active, cell-permeable, non-physiological ceramide analog. Induces a dramatic arrest in the G0/G1 phase of the cell cycle. Activates MAP kinase. Activates protein phosphatase 2A (PP2A) at 10 nM. Inhibits diacylglycerol accumulation and phospholipase D (PLD) activation in fibroblasts. Induces apoptosis in MOLT-4 leukemia cells.
Catalogue Number
376650
Brand Family
Calbiochem®
Synonyms
C₆ Ceramide
References
References
Jayadev, S., et al. 1995. J. Biol. Chem. 270, 2047. Venable, M.E., et al. 1994. J. Biol. Chem. 269, 26040. Dobrowsky, R.T., et al. 1993. J. Biol. Chem. 268, 15523. Raines, M.A., et al. 1993. J. Biol. Chem.268, 14572. Dobrowsky, R.T., and Hannun, Y.A. 1992. J. Biol. Chem.267, 5048.
D-erythro-Sphingosine, N-Hexanoyl- - CAS 124753-97-5 - Calbiochem Certificates of Analysis
Title
Lot Number
376650
References
Reference overview
Jayadev, S., et al. 1995. J. Biol. Chem. 270, 2047. Venable, M.E., et al. 1994. J. Biol. Chem. 269, 26040. Dobrowsky, R.T., et al. 1993. J. Biol. Chem. 268, 15523. Raines, M.A., et al. 1993. J. Biol. Chem.268, 14572. Dobrowsky, R.T., and Hannun, Y.A. 1992. J. Biol. Chem.267, 5048.
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
25-September-2019 JSW
Synonyms
C₆ Ceramide
Description
Biologically active, cell-permeable, nonphysiological ceramide analog. Stimulates cytosolic serine/threonine protein phosphatase in T9 cells and induces phosphorylation on Thr-669 in A-431 cells by stimulation of ceramide-activated protein kinase. Induces a dramatic arrest in the Go/G1 phase of the cell cycle. Activates MAP kinase. Activates protein phosphatase 2A (PP2A) at 10 nM. Inhibits diacylglycerol accumulation and phospholipase D activation in fibroblasts. Induces apoptosis in Molt-4 leukemia cells.
Form
White waxy solid
CAS number
124753-97-5
Chemical formula
C₂₄H₄₇NO₃
Structure formula
Purity
≥95% by TLC
Solubility
DMSO or Ethanol (25 mg/ml)
Storage
-20°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Toxicity
Irritant
References
Jayadev, S., et al. 1995. J. Biol. Chem. 270, 2047. Venable, M.E., et al. 1994. J. Biol. Chem. 269, 26040. Dobrowsky, R.T., et al. 1993. J. Biol. Chem. 268, 15523. Raines, M.A., et al. 1993. J. Biol. Chem.268, 14572. Dobrowsky, R.T., and Hannun, Y.A. 1992. J. Biol. Chem.267, 5048.
