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376650 D-erythro-Sphingosine, N-Hexanoyl- - CAS 124753-97-5 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
124753-97-5C₂₄H₄₇NO₃

Products

Catalogue NumberPackaging Qty/Pack
376650-5MGCN Plastic ampoule 5 mg
Description
OverviewBiologically active, cell-permeable, non-physiological ceramide analog. Induces a dramatic arrest in the G0/G1 phase of the cell cycle. Activates MAP kinase. Activates protein phosphatase 2A (PP2A) at 10 nM. Inhibits diacylglycerol accumulation and phospholipase D (PLD) activation in fibroblasts. Induces apoptosis in MOLT-4 leukemia cells.
Catalogue Number376650
Brand Family Calbiochem®
SynonymsC₆ Ceramide
References
ReferencesJayadev, S., et al. 1995. J. Biol. Chem. 270, 2047.
Venable, M.E., et al. 1994. J. Biol. Chem. 269, 26040.
Dobrowsky, R.T., et al. 1993. J. Biol. Chem. 268, 15523.
Raines, M.A., et al. 1993. J. Biol. Chem. 268, 14572.
Dobrowsky, R.T., and Hannun, Y.A. 1992. J. Biol. Chem. 267, 5048.
Product Information
CAS number124753-97-5
ATP CompetitiveN
FormWhite waxy solid
Hill FormulaC₂₄H₄₇NO₃
Chemical formulaC₂₄H₄₇NO₃
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetMAP kinase, protein phosphatase 2A (PP2A)
Primary Target IC<sub>50</sub>Effective concentration: 10 nM in activating protein phosphatase 2A (PP2A)
Purity≥95% by TLC
Physicochemical Information
Cell permeableY
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Global Trade Item Number
Catalogue Number GTIN
376650-5MGCN 04055977212952