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400015 Caspase-1 Inhibitor IV - CAS 154674-81-4 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
154674-81-4C₃₃H₄₂N₄O₁₀

Products

Catalogue NumberPackaging Qty/Pack
400015-1MGCN Plastic ampoule 1 mg
Description
OverviewA highly selective, competitive, cell-permeable, and irreversible inhibitor of caspase-1, caspase-4, and caspase-5. Inactivates the enzyme with a rate limited by diffusion and is relatively inert toward other bionucleophiles such as glutathione, making it an excellent candidate for in vivo studies of enzyme inhibition.
Catalogue Number400015
Brand Family Calbiochem®
SynonymsICE Inhibitor IV, Ac-YVAD-AOM
References
ReferencesGarcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Thornberry, N.A., et al. 1994. Biochemistry 33, 3934.
Product Information
CAS number154674-81-4
ATP CompetitiveN
FormWhite solid
Hill FormulaC₃₃H₄₂N₄O₁₀
Chemical formulaC₃₃H₄₂N₄O₁₀
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary Targetcaspase-1
Purity≥96% by HPLC
Physicochemical Information
Cell permeableY
Peptide SequenceAc-Tyr-Val-Ala-Asp-AOM (AOM = 2,6-dimethylbenzoyloxymethyl ketone)
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing recosntitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Global Trade Item Number
Catalogue Number GTIN
400015-1MGCN 07790788049935