Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

400012 Caspase-1 Inhibitor II - CAS 178603-78-6 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
178603-78-6C₂₄H₃₃ClN₄O₈

Products

Catalogue NumberPackaging Qty/Pack
400012-5MGCN Plastic ampoule 5 mg
Description
OverviewA cell-permeable and irreversible inhibitor of caspase-1 (Ki = 760 pM), caspase-4, and caspase-5. Inhibits Fas-mediated apoptosis and acidic sphingomyelinase activation.
Catalogue Number400012
Brand Family Calbiochem®
SynonymsIL-1β Converting Enzyme (ICE) Inhibitor II, Ac-YVAD-CMK
References
ReferencesBrenner, B., et al. 1998. Cell Death Differ. 5, 29.
Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
Enari, M., et al. 1995. Nature 375, 78.
Walker, N.P.C., et al. 1994. Cell 78, 343.
Thornberry, N., et al. 1992. Nature 356, 768.
Product Information
CAS number178603-78-6
ATP CompetitiveN
FormWhite solid
Hill FormulaC₂₄H₃₃ClN₄O₈
Chemical formulaC₂₄H₃₃ClN₄O₈
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationCaspase-1 Inhibitor II, CAS 178603-78-6, is a cell-permeable, irreversible inhibitor of caspase-1 (Ki = 760 pM), caspase-4, and caspase-5.
Biological Information
Primary Targetcaspase-1
Primary Target K<sub>i</sub>760 pM against caspase-1
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Peptide SequenceAc-Tyr-Val-Ala-Asp-CMK
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Global Trade Item Number
Catalogue Number GTIN
400012-5MGCN 07790788049928