203646 Sigma-AldrichBMP Inhibitor II, DMH1 - CAS 1206711-16-1 - Calbiochem
The BMP Inhibitor II, DMH1, also referenced under CAS 1206711-16-1, controls the biological activity of BMP. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
More>> The BMP Inhibitor II, DMH1, also referenced under CAS 1206711-16-1, controls the biological activity of BMP. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: ALK2/3 Inhibitor, DMH1, Bone Morphogenetic Protein Inhibitor, DMH1, 4-(6-(4-Isopropoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline
Recommended Products
Overview
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Key Spec Table
| CAS # | Empirical Formula |
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| 1206711-16-1 | C₂₄H₂₀N₄O |
Products
| Catalogue Number | Packaging | Qty/Pack | |
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| 203646-5MGCN | Glass bottle | 5 mg |
| Description | |
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| Overview | A cell-permeable, potent, and highly selective BMPR inhibitior (IC50 against human ALK2/BMPR-I = 107.9 nM), exhibiting no activity toward ALK5, ALK6, AMPK, FLK1/KDR/VEGRF2, or PDGFRβ. Comparing to its non-BMPR-selective structural analog dorsomorphin (Cat. Nos. 171260 & 171261), DMH1 is 12.5-times more potent in preventing BMP pathway-dependent dorsoventral development (EC100 = 0.2 µM) in zebrafish embryo in vivo, while being non-toxic to the fish embryo and exhibiting no effect against VEGF signaling-dependent intersomitic vessel formation even at concentrations as high as 50 µM. |
| Catalogue Number | 203646 |
| Brand Family | Calbiochem® |
| Synonyms | ALK2/3 Inhibitor, DMH1, Bone Morphogenetic Protein Inhibitor, DMH1, 4-(6-(4-Isopropoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline |
| References | |
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| References | Hao, J., et al. 2010. ACS Chem.Biol. 5, 245. |
| Product Information | |
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| CAS number | 1206711-16-1 |
| Form | Orange solid |
| Hill Formula | C₂₄H₂₀N₄O |
| Chemical formula | C₂₄H₂₀N₄O |
| Structure formula Image | |
| Quality Level | MQ100 |
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| Biological Information | |
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| Purity | ≥97% by HPLC |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 203646-5MGCN | 04055977204384 |
Documentation
BMP Inhibitor II, DMH1 - CAS 1206711-16-1 - Calbiochem SDS
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BMP Inhibitor II, DMH1 - CAS 1206711-16-1 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 203646 |
References
| Reference overview |
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| Hao, J., et al. 2010. ACS Chem.Biol. 5, 245. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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