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182516 Arp2/3 Complex Inhibitor II, CK-869 - CAS 388592-44-7 - Calbiochem

The Arp2/3 Complex Inhibitor II, CK-869 controls the biological activity of Arp2/3. This small molecule/inhibitor is primarily used for Cell Structure applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Actin Assembly Inhibitor XIV, 2-(3-Bromophenyl)-3-(2,4-dimethoxyphenyl)-1,3-thiazolidin-4-one, racemic, CK-0157869

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182516
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
388592-44-7C₁₇H₁₆BrNO₃S

Products

Catalogue NumberPackaging Qty/Pack
182516-25MGCN Glass bottle 25 mg
Description
OverviewA cell-permeable thiazolidinone compound that inhibits actin assembly mediated by actin-related protein Arp2/3 complex of human and bovine, but not yeast, species (IC50 = 11 µM against bovine Arp2/3). Shown to inhibit the actin filament "comet tails" formation around intracellular Listeria in infected SKOV3 cells (IC50 = 7 µM). Structrual studies indicate that CK-869 targets the hydrophobic core in subdomain 1 of Arp3. CK-666 (Cat. No. 182515) and CK-869 exhibit different modes of binding, resulting in their different yeast cross-reactivities. Supplied as a racemic mixture of the active 2S and the inactive 2R enantiomers. CK-312 (Cat. No. 182518) can serve as a negative control.
Catalogue Number182516
Brand Family Calbiochem®
SynonymsActin Assembly Inhibitor XIV, 2-(3-Bromophenyl)-3-(2,4-dimethoxyphenyl)-1,3-thiazolidin-4-one, racemic, CK-0157869
References
ReferencesNolen, B.J., et al. 2009. Nature 460, 1031.
Product Information
CAS number388592-44-7
FormOff-white solid
Hill FormulaC₁₇H₁₆BrNO₃S
Chemical formulaC₁₇H₁₆BrNO₃S
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
182516-25MGCN 04055977205060

Documentation

Arp2/3 Complex Inhibitor II, CK-869 - CAS 388592-44-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Arp2/3 Complex Inhibitor II, CK-869 - CAS 388592-44-7 - Calbiochem Certificates of Analysis

TitleLot Number
182516

References

Reference overview
Nolen, B.J., et al. 2009. Nature 460, 1031.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision10-May-2010 RFH
SynonymsActin Assembly Inhibitor XIV, 2-(3-Bromophenyl)-3-(2,4-dimethoxyphenyl)-1,3-thiazolidin-4-one, racemic, CK-0157869
DescriptionA cell-permeable thiazolidinone compound that inhibits actin assembly mediated by actin-related protein Arp2/3 complex of human and bovine, but not yeast, species (IC50 = 11 µM against bovine Arp2/3). Shown to inhibit the actin filament "comet tails" formation around intracellular Listeria in infected SKOV3 cells (IC50 = 7 µM). Structural studies indicate that CK-869 targets the hydrophobic core in subdomain 1 of Arp3. CK-666 and CK-869 exhibit different modes of binding, resulting in their different yeast cross-reactivities. Supplied as a racemic mixture of the active 2S and the inactive 2R enantiomers. CK-312 (Cat. No. 182518) can serve as a negative control.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number388592-44-7
Chemical formulaC₁₇H₁₆BrNO₃S
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesNolen, B.J., et al. 2009. Nature 460, 1031.