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07-402-25UG Anti-p70 S6 Kinase

Anti-p70 S6 Kinase Antibody is an antibody against p70 S6 Kinase for use in IP & WB.

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07-402-25UG
25 μg  
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Description
Catalogue Number07-402-25UG
Brand Family Upstate
Trade Name
  • Upstate
DescriptionAnti-p70 S6 Kinase
References
Product Information
FormatPurified
PresentationPurified antibody in 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide with 30% Glycerol.
Quality LevelMQ100
Applications
ApplicationAnti-p70 S6 Kinase Antibody is an antibody against p70 S6 Kinase for use in IP & WB.
Key Applications
  • Immunoprecipitation
  • Western Blotting
Biological Information
Immunogenpeptide corresponding to amino acids 26-43 of rat p70 S6 Kinase, with an N-terminal cysteine
ConcentrationPlease refer to lot specific datasheet.
HostRabbit
Specificityp70 S6 kinase
IsotypeIgG
Species Reactivity
  • Human
  • Mouse
  • Rat
Antibody TypePolyclonal Antibody
Entrez Gene Number
Entrez Gene SummaryThis gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates several residues of the S6 ribosomal protein. The kinase activity of this protein leads to an increase in protein synthesis and cell proliferation. Amplification of the region of DNA encoding this gene and overexpression of this kinase are seen in some breast cancer cell lines. Alternate translational start sites have been described and alternate transcriptional splice variants have been observed but have not been thoroughly characterized.
Gene Symbol
  • RPS6KB1
  • p70-alpha
  • p70S6k
  • p70-S6K
  • p70
  • S6K
  • S6Kalpha)
  • P70S6K
  • STK14A
  • S6K1
  • p70(S6K)-alpha
  • PS6K
Purification MethodProtein A Purfied
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P23443 # Phosphorylates specifically ribosomal protein S6 in response to insulin or several classes of mitogens.
SIZE: 525 amino acids; 59140 Da
SUBUNIT: Interacts with PPP1R9A/neurabin-1 (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cell junction, synapse, synaptosome (By similarity).
TISSUE SPECIFICITY: Widely expressed.
SIMILARITY: SwissProt: P23443 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 protein kinase domain.
Molecular Weight64 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assuranceroutinely evaluated by immunoblot in RIPA lysates from HEK293, PC-12,and A431 cells
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions2 years at -20°C
Packaging Information
Material Size25 μg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
07-402-25UG 04054839342493

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