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MABF376 Sigma-AldrichAnti-CD11c Antibody (mouse), PE-Cy7, clone N418

This armenian hamster monoclonal antibody Anti-CD11c (mouse), PE-Cy7, clone N418 validated for use in IP, IHC, Immunofluorescence & Flow Cytometry for the detection of CD11c.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

SDS
CoA

Research Category: Inflammation & Immunology Gene Symbol: Itgax UniProt Number: Q9QXH4

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Overview

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Key Spec Table

Species Reactivity	Key Applications	Host	Format	Antibody Type
M	IP, IHC, IF, FC	AHm	PE-Cy7	Monoclonal Antibody

Description
Catalogue Number	MABF376
Description	Anti-CD11c Antibody (mouse), PE-Cy7, clone N418
Alternate Names	Integrin alpha-Xl CD11 antigen-like family member C Leukocyte adhesion glycoprotein p150,95 alpha chain Leukocyte adhesion receptor p150,95 CD11c
Background Information	The N418 antibody reacts with mouse CD11c, also known as integrin alpha X. This 150 kDa cell surface glycoprotein is part of a family of integrin receptors that mediate adhesion between cells (cell-cell) and components of the extracellular matrix, e.g. fibrinogen (cell-matrix). In addition, integrins are active signaling receptors which recruit leukocytes to inflammatory sites and promote cell activation. Complete, functional integrin receptors consist of distinct combinations of integrin chains which are differentially expressed. Integrin alpha X (CD11c) assembles with Integrin beta-2 (CD18) into a receptor complex known as CR4 which can bind and induce signaling throµgh ICAMs and VCAM-1 on endothelial cells and can also facilitate removal of iC3b bearing foreign cells.The N418 antibody is widely used as a marker for CD11c expression on dendritic cells (DC), often in parallel with markers for CD11b, for identification of developmental stages and mature subsets of this cell type. CD11c is prominently expressed on tissue macrophages, and is also detected on some types of activated T cells and intestinal intraepithelial lymphocytes (IEL).

References

Product Information
Format	PE-Cy7
Presentation	Purified Armenian Hamster Monoclonal Antibody in buffer containing 10 mM NaH2PO4, 150 mM NaCl, 0.1% gelatin, pH 7.2, and up to 0.1% sodium azide.
Quality Level	MQ100

Applications
Application	This armenian hamster monoclonal antibody Anti-CD11c (mouse), PE-Cy7, clone N418 validated for use in IP, IHC, Immunofluorescence & Flow Cytometry for the detection of CD11c.
Key Applications	Immunoprecipitation Immunohistochemistry Immunofluorescence Flow Cytometry

Biological Information
Immunogen	Immunogen information for this antibody is proprietary information.
Clone	N418
Concentration	0.2 mg/mL
Host	Armenian Hamster
Isotype	IgG
Species Reactivity	Mouse
Antibody Type	Monoclonal Antibody
Gene Symbol	Itgax
Purification Method	Size Exclusion Chromatography
UniProt Number	Q9QXH4

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	The monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation. Flow Cytometry Analysis: 1 µg of this antibody detected CD11c in one million C57Bl/6 splenocytes.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	It is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.

Packaging Information
Material Size	100 µg

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
Catalogue Number	GTIN
MABF376	04053252959783

Documentation

Anti-CD11c Antibody (mouse), PE-Cy7, clone N418 SDS

Title
Safety Data Sheet (SDS)

Anti-CD11c Antibody (mouse), PE-Cy7, clone N418 Certificates of Analysis

Title	Lot Number
Anti-CD11c (mouse), PE-Cy7, clone N418 - TN14021204	TN14021204

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