Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

05-23-0101 Angiotensin II, Human - CAS 4474-91-3 - Calbiochem

Plays an important role in the regulation of blood pressure.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: DRVYIHPF

Primary Target: adenylate cyclase activity
View Products on Sigmaaldrich.com
05-23-0101
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
4474-91-3C₅₀H₇₁N₁₃O₁₂

Products

Catalogue NumberPackaging Qty/Pack
05230101-1MGCN Plastic ampoule 1 mg
05230101-25MGCN Glass bottle 25 mg
05230101-5MGCN Plastic ampoule 5 mg
Description
OverviewPlays an important role in the regulation of blood pressure. Stimulates the release of aldosterone from the adrenal gland. Inhibits adenylate cyclase activity in spontaneously hypertensive rats. Has strong vasoconstrictive effects. Increases the entry of Ca2+ in heart muscle via voltage-sensitive channels and activates myosin light chain kinase. Also elicits an increase in voltage-dependent delayed rectifier K+ current in neurons. Activates JAK2 in smooth muscle cells. Activates p125FAK and a cytosolic 115-120 kDa calcium-dependent tyrosine kinase in rat epithelial cells. Also activates p60c-src as well as ERK1/2, JNK, and p38 MAP Kinase in vascular smooth muscle cells.
Catalogue Number05-23-0101
Brand Family Calbiochem®
SynonymsDRVYIHPF
References
ReferencesZhu, M., et al. 2000. J. Neurophysiol. 84, 2494.
Natarajan, R., et al. 1999. Hypertension 33, 378.
Mazzolai, L., et al. 1998. Hypertension 31, 1324.
Earp, H.S., et al. 1995. J. Biol. Chem. 270, 28440.
Ishida, M., et al. 1995. Circ. Res. 77, 1053.
Vyas, S.J., and Jackson, E.K. 1995. J. Pharmacol. Exp. Ther. 273, 768.
Product Information
CAS number4474-91-3
ATP CompetitiveN
FormWhite to off-white solid
Hill FormulaC₅₀H₇₁N₁₃O₁₂
Chemical formulaC₅₀H₇₁N₁₃O₁₂
Hygroscopic Hygroscopic
ReversibleN
Sold on the basis of peptide contentY
Quality LevelMQ100
Applications
Biological Information
Primary Targetadenylate cyclase activity
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Peptide ContentY
Peptide SequenceH-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-OH
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSBW2165000
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 week at 4°C or for up to 1 month at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
05230101-1MGCN 04055977206906
05230101-25MGCN 04055977206913
05230101-5MGCN 04055977206920

Documentation

Angiotensin II, Human - CAS 4474-91-3 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Angiotensin II, Human - CAS 4474-91-3 - Calbiochem Certificates of Analysis

TitleLot Number
05-23-0101

References

Reference overview
Zhu, M., et al. 2000. J. Neurophysiol. 84, 2494.
Natarajan, R., et al. 1999. Hypertension 33, 378.
Mazzolai, L., et al. 1998. Hypertension 31, 1324.
Earp, H.S., et al. 1995. J. Biol. Chem. 270, 28440.
Ishida, M., et al. 1995. Circ. Res. 77, 1053.
Vyas, S.J., and Jackson, E.K. 1995. J. Pharmacol. Exp. Ther. 273, 768.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-May-2008 JSW
SynonymsDRVYIHPF
DescriptionFunctions in blood pressure maintenance. Stimulates the release of aldosterone from the adrenal gland. Has strong vasoconstrictive effects. Increases the entry of Ca2+ in heart muscle via voltage-sensitive channels and activates myosin light chain kinase. Activates JAK2 in smooth muscle cells. Activates p125FAK and a cytosolic 115-120 kDa calcium-dependent tyrosine kinase in rat epithelial cells. Also activates pp60c-src in vascular smooth muscle cells. Inhibits adenylate cyclase activity in spontaneously hypertensive rats.
FormWhite to off-white solid
CAS number4474-91-3
RTECSBW2165000
Chemical formulaC₅₀H₇₁N₁₃O₁₂
Peptide SequenceH-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-OH
Purity≥98% by HPLC
Solubility5% acetic acid (1 mg/ml) or H₂O (1 mg/ml)
Storage -20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 week at 4°C or for up to 1 month at -20°C.
Toxicity Standard Handling
Merck USA index14 651
ReferencesZhu, M., et al. 2000. J. Neurophysiol. 84, 2494.
Natarajan, R., et al. 1999. Hypertension 33, 378.
Mazzolai, L., et al. 1998. Hypertension 31, 1324.
Earp, H.S., et al. 1995. J. Biol. Chem. 270, 28440.
Ishida, M., et al. 1995. Circ. Res. 77, 1053.
Vyas, S.J., and Jackson, E.K. 1995. J. Pharmacol. Exp. Ther. 273, 768.