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176708 Angiostatin K1-3, Human, Recombinant, E. coli

Angiostatin K1-3 is a recombinant form expressed in E. coli as a single, non-glycosylated polypeptide chain of 259 amino acids. A specific inhibitor of endothelial cell growth and angiogenesis.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Ang K1-3, K1-3, rHuAng K1-3

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176708
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Overview

Replacement Information

Products

Catalogue NumberPackaging Qty/Pack
176708-250UGCN Glass bottle 250 μg
Description
OverviewRecombinant, human angiostatin expressed in E. coli as a single, nonglycosylated polypeptide chain containing 259 amino acids. Represents a proteolytic fragment containing the first three kringle structures of plasminogen. Acts as a specific inhibitor of endothelial cell growth and angiogenesis. Displays increased inhibitory activity (ED50=70 nM) relative to kringles 1-4 (ED50=135 nm).
Catalogue Number176708
Brand Family Calbiochem®
SynonymsAng K1-3, K1-3, rHuAng K1-3
References
ReferencesCao, R., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 5728.
Cao, E., et al. 1997. J. Biol. Chem. 272, 22924.
Sim, B.K., et al. 1997. Cancer Res. 57, 1329.
Wu, Z., et al. 1997. Biochem. Biophys. Res. Commun. 236, 651.
O'Rieilly, M.S., et al. 1994. Cell 79, 315.
Peterson, T.E., et al. 1990. J. Biol. Chem. 265, 6104.
Forsgren, M., et al. 1987. FEBS Lett. 213, 254.
Malinowski, D.P., et al. 1984. Biochemistry 23, 4243.
Product Information
FormLyophilized powder
FormulationLyophilized from 20 mM Sodium Acetate, 4% Mannitol, pH 5.5.
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC and SDS-PAGE
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Standard Handling
Storage -20°C
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
176708-250UGCN 04055977222968

Documentation

Angiostatin K1-3, Human, Recombinant, E. coli SDS

Title

Safety Data Sheet (SDS) 

Angiostatin K1-3, Human, Recombinant, E. coli Certificates of Analysis

TitleLot Number
176708

References

Reference overview
Cao, R., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 5728.
Cao, E., et al. 1997. J. Biol. Chem. 272, 22924.
Sim, B.K., et al. 1997. Cancer Res. 57, 1329.
Wu, Z., et al. 1997. Biochem. Biophys. Res. Commun. 236, 651.
O'Rieilly, M.S., et al. 1994. Cell 79, 315.
Peterson, T.E., et al. 1990. J. Biol. Chem. 265, 6104.
Forsgren, M., et al. 1987. FEBS Lett. 213, 254.
Malinowski, D.P., et al. 1984. Biochemistry 23, 4243.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision06-July-2010 RFH
SynonymsAng K1-3, K1-3, rHuAng K1-3
DescriptionRecombinant, human angiostatin expressed in E. coli as a single, nonglycosylated polypeptide chain containing 259 amino acids. Represents a proteolytic fragment containing the first three kringle structures of plasminogen. Acts as a specific inhibitor of endothelial cell growth and angiogenesis. Displays increased inhibitory activity (ED50=70 nM) relative to kringles 1-4 (ED50=135 nm).
FormLyophilized powder
FormulationLyophilized from 20 mM Sodium Acetate, 4% Mannitol, pH 5.5.
Purity≥95% by HPLC and SDS-PAGE
SolubilityH2O or Aqueous Buffer Containing 0.1% BSA
Storage Avoid freeze/thaw
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesCao, R., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 5728.
Cao, E., et al. 1997. J. Biol. Chem. 272, 22924.
Sim, B.K., et al. 1997. Cancer Res. 57, 1329.
Wu, Z., et al. 1997. Biochem. Biophys. Res. Commun. 236, 651.
O'Rieilly, M.S., et al. 1994. Cell 79, 315.
Peterson, T.E., et al. 1990. J. Biol. Chem. 265, 6104.
Forsgren, M., et al. 1987. FEBS Lett. 213, 254.
Malinowski, D.P., et al. 1984. Biochemistry 23, 4243.