124030 Sigma-AldrichAkt Inhibitor XIII, Isozyme-Selective, Akti2-1/2 - Calbiochem
The Akt Inhibitor XIII, Isozyme-Selective, Akti2-1/2 controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
More>> The Akt Inhibitor XIII, Isozyme-Selective, Akti2-1/2 controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: N-(2-(Diethylamino)ethyl)-3-(4-((4-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl)methyl)phenyl)-2-phenyl-6-quinolinecarboxamide, 3HCl, N-(2-(Diethylamino)ethyl)-2-(4-((4-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl)methyl)phenyl)-3-phenyl-6-quinolinecarboxamide, 3HCl and
Recommended Products
Overview
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Key Spec Table
| Empirical Formula |
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| C₄₀H₄₃N₇O₂ • 3HCl |
Products
| Catalogue Number | Packaging | Qty/Pack | |
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| 124030-2MGCN | Glass bottle | 2 mg |
| Description | |
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| Overview | A highly cell-permeable and water soluble analog of Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 (Cat. No. 124018) that acts as a plecktrin homology (PH)-domain dependent, non-ATP competitive and an allosteric inhibitor of Akt1/2 (IC50 = 560 nM, 390 nM and 7.8 µM in in vitro kinase assay; 526 nM, 730 nM and > 10 µM in LNCaP cells for Akt1, Akt2 and Akt3, respectively) with ~ 80-fold greater selectivity over PKA, PKC and SGK (IC50 > 50 µM). One of its potent regioisomers (C7-substituted) is shown to enhance induced caspase-3 activity in several tumor cells. |
| Catalogue Number | 124030 |
| Brand Family | Calbiochem® |
| Synonyms | N-(2-(Diethylamino)ethyl)-3-(4-((4-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl)methyl)phenyl)-2-phenyl-6-quinolinecarboxamide, 3HCl, N-(2-(Diethylamino)ethyl)-2-(4-((4-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl)methyl)phenyl)-3-phenyl-6-quinolinecarboxamide, 3HCl and |
| References | |
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| References | Zhao, Z., et al. 2008. Bioorg. Med. Chem. Lett. 18, 49. |
| Product Information | |
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| Form | Yellow solid |
| Hill Formula | C₄₀H₄₃N₇O₂ • 3HCl |
| Chemical formula | C₄₀H₄₃N₇O₂ • 3HCl |
| Hygroscopic | Hygroscopic |
| Structure formula Image | |
| Quality Level | MQ100 |
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| Biological Information | |
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| Purity | ≥97% by HPLC (mixture of regioisomers) |
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| Safety Information according to GHS |
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| Product Usage Statements |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 124030-2MGCN | 04055977205770 |
Documentation
Akt Inhibitor XIII, Isozyme-Selective, Akti2-1/2 - Calbiochem SDS
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Akt Inhibitor XIII, Isozyme-Selective, Akti2-1/2 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 124030 |
References
| Reference overview |
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| Zhao, Z., et al. 2008. Bioorg. Med. Chem. Lett. 18, 49. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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