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190080 AY 9944 - CAS 366-93-8 - Calbiochem

A cell-permeable amphiphilic diamine that blocks cholesterol biosynthesis and its esterification.

AY 9944 - CAS 366-93-8 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: trans-1,4-bis(2-Chlorobenzylaminomethyl)cyclohexane, 2HCl, Shh Signaling Antagonist IV

Primary Target: 7-dehydrocholesterol reductase (δ7-sterol reductase)
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190080
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
366-93-8C₂₂H₂₈Cl₂N₂ • 2HCl

Products

Catalogue NumberPackaging Qty/Pack
190080-5MGCN Glass bottle 5 mg
Description
OverviewA cell-permeable amphiphilic diamine that blocks cholesterol biosynthesis and its esterification. Specifically blocks 7-dehydrocholesterol reductase (Δ7-sterol reductase) activity with IC50= 13 nM. Important tool in Sonic Hedgehog signaling and teratogenicity studies. Also reported to induce a rapid and irreversible reduction in Acidic-Sphingomyelinase activity in fibroblasts.
Catalogue Number190080
Brand Family Calbiochem®
Synonymstrans-1,4-bis(2-Chlorobenzylaminomethyl)cyclohexane, 2HCl, Shh Signaling Antagonist IV
References
ReferencesGofflot, F., et al. 2001. Dev. Dyn. 220, 99.
Cooper, M.K., et al. 1998. Science 280, 1603.
Incardona, J.P., et al. 1998. Development 125, 3553.
Moebius, F.F., et al. 1998. Proc. Natl. Acad. Sci. USA95, 1899.
Yoshida, Y. 1985. J. Biochem. 98, 1669.
Kraml, M., et al. 1964. Biochem. Biophys. Res. Commun. 15, 455.
Product Information
CAS number366-93-8
ATP CompetitiveN
FormWhite solid
Hill FormulaC₂₂H₂₈Cl₂N₂ • 2HCl
Chemical formulaC₂₂H₂₈Cl₂N₂ • 2HCl
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Target7-dehydrocholesterol reductase (δ7-sterol reductase)
Primary Target IC<sub>50</sub>13 nM in blocking 7-dehydrocholesterol reductase (δ7-sterol reductase) activity
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSGU7025000
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful & Carcinogenic / Teratogenic
Storage +2°C to +8°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
190080-5MGCN 04055977221336

Documentation

AY 9944 - CAS 366-93-8 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

AY 9944 - CAS 366-93-8 - Calbiochem Certificates of Analysis

TitleLot Number
190080

References

Reference overview
Gofflot, F., et al. 2001. Dev. Dyn. 220, 99.
Cooper, M.K., et al. 1998. Science 280, 1603.
Incardona, J.P., et al. 1998. Development 125, 3553.
Moebius, F.F., et al. 1998. Proc. Natl. Acad. Sci. USA95, 1899.
Yoshida, Y. 1985. J. Biochem. 98, 1669.
Kraml, M., et al. 1964. Biochem. Biophys. Res. Commun. 15, 455.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision01-October-2007 JSW
Synonymstrans-1,4-bis(2-Chlorobenzylaminomethyl)cyclohexane, 2HCl, Shh Signaling Antagonist IV
DescriptionA cell-permeable, amphiphilic diamine that acts as a potent inhibitor of cholesterol biosynthesis and esterification and exhibits teratogenic properties. Specifically blocks 7-dehydro-cholesterol reductase (Δ7-sterol reductase; DHC) activity with IC50= 13 nM. Reported to disrupt Sonic Hedgehog (Shh) signaling during embryogenesis in rats. Also reported to induce a rapid and irreversible reduction in acidic-sphingomyelinase activity in fibroblasts.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number366-93-8
RTECSGU7025000
Chemical formulaC₂₂H₂₈Cl₂N₂ • 2HCl
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityH₂O (20 mg/ml) or DMSO (20 mg/ml)
Storage +2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Harmful & Carcinogenic / Teratogenic
ReferencesGofflot, F., et al. 2001. Dev. Dyn. 220, 99.
Cooper, M.K., et al. 1998. Science 280, 1603.
Incardona, J.P., et al. 1998. Development 125, 3553.
Moebius, F.F., et al. 1998. Proc. Natl. Acad. Sci. USA95, 1899.
Yoshida, Y. 1985. J. Biochem. 98, 1669.
Kraml, M., et al. 1964. Biochem. Biophys. Res. Commun. 15, 455.