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208719 ALLN - CAS 110044-82-1 - Calbiochem

ALLN, CAS 110044-82-1, is a cell-permeable inhibitor of calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM).

ALLN - CAS 110044-82-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: LLNL, MG 101, Calpain Inhibitor I, Proteasome Inhibitor V

Primary Target: Calpain-1
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208719
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
110044-82-1C₂₀H₃₇N₃O₄

Products

Catalogue NumberPackaging Qty/Pack
208719-25MGCN Plastic ampoule 25 mg
208719-5MGCN Plastic ampoule 5 mg
Description
OverviewCell-permeable inhibitor of calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM). Inhibits neutral cysteine proteases and the proteasome (Ki = 6 µM). Modulates the processing of the β-amyloid precursor protein (βAPP) to β-amyloid (Aβ). Protects against neuronal damage caused by hypoxia and ischemia. Inhibits apoptosis in thymocytes and metamyelocytes. Also inhibits reovirus-induced apoptosis in L929 cells. Inhibits the proteolysis of IκB-α and IκB-β by the ubiquitin-proteasome complex. Inhibits cell cycle progression at G1/S and metaphase/anaphase in CHO cells by inhibiting cyclin B degradation. Also prevents nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene. A 10 mM (5 mg/1.30 ml) solution of ALLN (Cat. No. 208750) in DMSO is also available.
Catalogue Number208719
Brand Family Calbiochem®
SynonymsLLNL, MG 101, Calpain Inhibitor I, Proteasome Inhibitor V
References
ReferencesDebiasi, R.L., et al. 1999. J. Virol. 73, 695.
Zhang, L., et al. 1999. J. Biol. Chem. 274, 8966.
Milligan, S.A., et al. 1996. Arch. Biochem. Biophys. 335, 388.
Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun. 215, 721.
Squier, M.K., et al. 1994. J. Cell Physiol. 159, 229.
Rami, J., and Kreiglstein, J. 1993. Brain Res. 609, 67.
Sherwood, S.W., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 3353.
Vinitsky, A., et al. 1992. Biochemistry 31, 9421.
Sasaki, T., et al. 1990. J. Enzyme Inhib. 3, 195.
Product Information
CAS number110044-82-1
ATP CompetitiveN
FormWhite to off-white solid
Hill FormulaC₂₀H₃₇N₃O₄
Chemical formulaC₂₀H₃₇N₃O₄
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationALLN, CAS 110044-82-1, is a cell-permeable inhibitor of calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM).
Biological Information
Primary TargetCalpain-1
Primary Target K<sub>i</sub>190 nM, 220 nM, 150 nM, 500 pM, against calpain I, calpain II, cathepsin B, and cathepsin L, respectively
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Peptide SequenceN-Acetyl-Leu-Leu-Nle-CHO
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
208719-25MGCN 04055977202656
208719-5MGCN 04055977202663

Documentation

ALLN - CAS 110044-82-1 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

ALLN - CAS 110044-82-1 - Calbiochem Certificates of Analysis

TitleLot Number
208719

References

Reference overview
Debiasi, R.L., et al. 1999. J. Virol. 73, 695.
Zhang, L., et al. 1999. J. Biol. Chem. 274, 8966.
Milligan, S.A., et al. 1996. Arch. Biochem. Biophys. 335, 388.
Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun. 215, 721.
Squier, M.K., et al. 1994. J. Cell Physiol. 159, 229.
Rami, J., and Kreiglstein, J. 1993. Brain Res. 609, 67.
Sherwood, S.W., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 3353.
Vinitsky, A., et al. 1992. Biochemistry 31, 9421.
Sasaki, T., et al. 1990. J. Enzyme Inhib. 3, 195.

Brochure

Title
Caspases and other Apoptosis Related Tools Brochure
Proteasomes Technical Bulletin

Citations

Title
  • Ping Han, et al. (2005) Suppression of Cyclin-Dependent Kinase 5 Activation by Amyloid Precursor Protein: A Novel Excitoprotective Mechanism Involving Modulation of Tau Phosphorylation. Journal of Neuroscience 25, 11542-11552.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision03-October-2007 RFH
    SynonymsLLNL, MG 101, Calpain Inhibitor I, Proteasome Inhibitor V
    DescriptionInhibitor of calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM). Inhibits neutral cysteine proteases and proteasome (Ki = 6 µM). Protects against neuronal damage caused by hypoxia and ischemia. Inhibits apoptosis in thymocytes and metamyelocytes. Inhibits cell cycle progression at the G1/S border and metaphase/anaphase in CHO cells by inhibiting cyclin B degradation. Also prevents nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene. Inhibits the proteolysis of IκBα and IκBβ by the ubiquitin-proteasome complex.
    FormWhite to off-white solid
    CAS number110044-82-1
    Chemical formulaC₂₀H₃₇N₃O₄
    Peptide SequenceN-Acetyl-Leu-Leu-Nle-CHO
    Structure formulaStructure formula
    Purity≥95% by HPLC
    SolubilityDMSO (10 mg/ml) or Ethanol (5 mg/ml)
    Storage +2°C to +8°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    Toxicity Standard Handling
    ReferencesDebiasi, R.L., et al. 1999. J. Virol. 73, 695.
    Zhang, L., et al. 1999. J. Biol. Chem. 274, 8966.
    Milligan, S.A., et al. 1996. Arch. Biochem. Biophys. 335, 388.
    Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun. 215, 721.
    Squier, M.K., et al. 1994. J. Cell Physiol. 159, 229.
    Rami, J., and Kreiglstein, J. 1993. Brain Res. 609, 67.
    Sherwood, S.W., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 3353.
    Vinitsky, A., et al. 1992. Biochemistry 31, 9421.
    Sasaki, T., et al. 1990. J. Enzyme Inhib. 3, 195.
    Citation
  • Ping Han, et al. (2005) Suppression of Cyclin-Dependent Kinase 5 Activation by Amyloid Precursor Protein: A Novel Excitoprotective Mechanism Involving Modulation of Tau Phosphorylation. Journal of Neuroscience 25, 11542-11552.
    		•

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    Categories

    Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Proteases Inhibitors > Proteasome and Ubiquitination Pathway Inhibitors
    Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Proteases Inhibitors
    Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Proteases Inhibitors > Calpain Inhibitors