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126920 ALDH2 Agonist, Alda-1 - CAS 349438-38-6 - Calbiochem

ALDH2 Agonist, Alda-1, CAS 349438-38-6, is a cell-permeable, selective enhancer the activity of both the wild-type ALDH2*1 and the East Asian E487K mutant ALDH2*2 forms of mitochondrial ALDH2.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-(1,3-Benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide

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126920
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
349438-38-6C₁₅H₁₁Cl₂NO₃

Products

Catalogue NumberPackaging Qty/Pack
126920-25MGCN Plastic ampoule 25 mg
Description
OverviewA cell-permeable benzamide compound that selectively enhances the activity of both the wild-type ALDH2*1 and the east asian E487K mutant ALDH2*2 forms of mitochondrial aldehyde dehydrogenase 2 (2.1-, 2.2, and 11-fold activation of 20 µg wt homo, wt/mut hetero, and mut homo tetramer, respectively, at 100 µM), while exhibiting no effect toward alcohol dehydrogenase 1, cytosolic ALDH1, or mitochondrial ALDH5. Both PKCε activatior- and ethanol-mediated protections against heart tissue ischemic damage are reported to correlate well with ALDH2 activation, and Alda-1, likewise, is shown to protect against ischemic tissue damage to excised rat hearts (26% and 24% reduction in infarct size and CPK release, respectively; 20 µM) ex vivo and anesthetized live rats (60% infarction reduction; 8.5 mg/kg) in vivo.
Catalogue Number126920
Brand Family Calbiochem®
SynonymsN-(1,3-Benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide
References
ReferencesChen, C.H., et al. 2008. Science 321, 1493.
Product Information
CAS number349438-38-6
DeclarationPatent pending.
FormOff-white solid
Hill FormulaC₁₅H₁₁Cl₂NO₃
Chemical formulaC₁₅H₁₁Cl₂NO₃
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationALDH2 Agonist, Alda-1, CAS 349438-38-6, is a cell-permeable, selective enhancer the activity of both the wild-type ALDH2*1 and the East Asian E487K mutant ALDH2*2 forms of mitochondrial ALDH2.
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing, reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
126920-25MGCN 04055977222173

Documentation

ALDH2 Agonist, Alda-1 - CAS 349438-38-6 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

ALDH2 Agonist, Alda-1 - CAS 349438-38-6 - Calbiochem Certificates of Analysis

TitleLot Number
126920

References

Reference overview
Chen, C.H., et al. 2008. Science 321, 1493.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision20-March-2014 JSW
SynonymsN-(1,3-Benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide
DescriptionA cell-permeable benzamide compound that selectively enhances the activity of both the wild-type ALDH2*1 and the east asian E487K mutant ALDH2*2 forms of mitochondrial aldehyde dehydrogenase 2 (2.1-, 2.2, and 11-fold activation of 20 µg wt homo, wt/mut hetero, and mut homo tetramer, respectively, at 100 µM), while exhibiting no effect toward alcohol dehydrogenase 1, cytosolic ALDH1, or mitochondrial ALDH5. Both PKCε activatior- and ethanol-mediated protections against heart tissue ischemic damage are reported to correlate well with ALDH2 activation, and Alda-1, likewise, is shown to protect against ischemic tissue damage to excised rat hearts (26% and 24% reduction in infarct size and CPK release, respectively; 20 µM) ex vivo and anesthetized live rats (60% infarction reduction; 8.5 mg/kg) in vivo.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number349438-38-6
Chemical formulaC₁₅H₁₁Cl₂NO₃
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (100 mg/ml) or Ethanol (10 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing, reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesChen, C.H., et al. 2008. Science 321, 1493.