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189825 5-Aza-2ʹ-Deoxycytidine - CAS 2353-33-5 - Calbiochem

5-Aza-2ʹ-Deoxycytidine, CAS 2353-33-5, is a cytosine analog that acts as a suicide substrate and inhibits DNA methyltransferase activity.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 5-Aza-CdR, 5-Aza-dC, 2'-Deoxy-5-azacytidine, Decitabine

Primary Target: DNA methyltransferase inhibitor
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189825
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
2353-33-5C₈H₁₂N₄O₄

Products

Catalogue NumberPackaging Qty/Pack
189825-25MGCN Plastic ampoule 25 mg
Description
OverviewA cytosine analog that acts as a DNA methyltransferase inhibitor. Restores caspase-8 and caspase-10 mRNA and protein expression as well as TRAIL (Tumor necrosis factor-Related Apoptosis Inducing Ligand) sensitivity in TRAIL-resistant cell lines. Also enhances apoptosis induced by HDAC (Histone Deacetylase) inhibitors. Also available as a 100 mM solution in DMSO (Cat. No. 189826).
Catalogue Number189825
Brand Family Calbiochem®
Synonyms5-Aza-CdR, 5-Aza-dC, 2'-Deoxy-5-azacytidine, Decitabine
References
ReferencesEggert, A., et al. 2001. Cancer Res. 61, 1314.
Takebayashi, S., et al. 2001. Biochem. Biophys. Res. Commun. 288, 921.
Zhu, W.G., et al. 2001. Cancer Res. 61, 1327.
Hopkins-Donaldson, S., et al. 2000. Cancer Res. 60, 4315.
Haaf, T. 1995. Pharmacol. Ther. 65, 19.
Jones, P.A., and Taylor, S.M. 1980. Cell 20, 85.
Product Information
CAS number2353-33-5
FormLyophilized
Hill FormulaC₈H₁₂N₄O₄
Chemical formulaC₈H₁₂N₄O₄
Structure formula ImageStructure formula Image
Quality LevelMQ200
Applications
Application5-Aza-2ʹ-Deoxycytidine, CAS 2353-33-5, is a cytosine analog that acts as a suicide substrate and inhibits DNA methyltransferase activity.
Biological Information
Primary TargetDNA methyltransferase inhibitor
Purity≥ 98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSXZ3012000
Safety Information
R PhraseR: 20/21/22-36/37/38-43-61

Harmful by inhalation, in contact with skin and if swallowed.
Irritating to eyes, respiratory system and skin.
May cause sensitization by skin contact.
May cause harm to the unborn child.
S PhraseS: 22-26-36/37/39-45

Do not breathe dust.
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful & Carcinogenic / Teratogenic
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
189825-25MGCN 04055977222043

Documentation

5-Aza-2ʹ-Deoxycytidine - CAS 2353-33-5 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

5-Aza-2ʹ-Deoxycytidine - CAS 2353-33-5 - Calbiochem Certificates of Analysis

TitleLot Number
189825

References

Reference overview
Eggert, A., et al. 2001. Cancer Res. 61, 1314.
Takebayashi, S., et al. 2001. Biochem. Biophys. Res. Commun. 288, 921.
Zhu, W.G., et al. 2001. Cancer Res. 61, 1327.
Hopkins-Donaldson, S., et al. 2000. Cancer Res. 60, 4315.
Haaf, T. 1995. Pharmacol. Ther. 65, 19.
Jones, P.A., and Taylor, S.M. 1980. Cell 20, 85.

Brochure

Title
Caspases and other Apoptosis Related Tools Brochure

Technical Info

Title
White Paper - The Message in the Marks: Deciphering Cancer Epigenetics
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision17-December-2008 JSW
Synonyms5-Aza-CdR, 5-Aza-dC, 2'-Deoxy-5-azacytidine, Decitabine
DescriptionA cytosine analog that acts as a DNA methyltransferase inhibitor. Shown to restore mRNA and protein expression of caspase-8 and Tumor Necrosis Factor-Related Apoptosis Inducing Ligand (TRAIL) sensitivity of resistant cell lines. Also reported to enhance apoptosis induced by histone deacetylase (HDAC) inhibitors.
FormLyophilized
Intert gas (Yes/No) Packaged under inert gas
CAS number2353-33-5
RTECSXZ3012000
Chemical formulaC₈H₁₂N₄O₄
Structure formulaStructure formula
Purity≥ 98% by HPLC
SolubilityDMSO (25 mg/ml), 50% Acetic Acid (25 mg/ml), or Methanol (1 mg/ml) (warming is required to achieve complete solubilization)
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Harmful & Carcinogenic / Teratogenic
ReferencesEggert, A., et al. 2001. Cancer Res. 61, 1314.
Takebayashi, S., et al. 2001. Biochem. Biophys. Res. Commun. 288, 921.
Zhu, W.G., et al. 2001. Cancer Res. 61, 1327.
Hopkins-Donaldson, S., et al. 2000. Cancer Res. 60, 4315.
Haaf, T. 1995. Pharmacol. Ther. 65, 19.
Jones, P.A., and Taylor, S.M. 1980. Cell 20, 85.