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565763 γ-Secretase Inhibitor VI - CAS 287196-57-0 - Calbiochem

The γ-Secretase Inhibitor VI, also referenced under CAS 287196-57-0, controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1-(S)-endo-N-(1,3,3)-Trimethylbicyclo[2.2.1]hept-2-yl)-4-fluorophenyl Sulfonamide

Primary Target: Aβ₄₂ production
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
287196-57-0C₁₆H₂₂FNO₂S

Products

Catalogue NumberPackaging Qty/Pack
565763-5MGCN Plastic ampoule 5 mg
Description
OverviewCell permeable. Potently inhibits Aβ42 production (IC50 = 1.8 µM). Treatment of HEK293 cells with this inhibitor results in β-Secretase-cleaved APP fragments and secreted APPα, but no change in secreted APPsβ is observed indicating specific inhibition of γ-secretase.
Catalogue Number565763
Brand Family Calbiochem®
Synonyms1-(S)-endo-N-(1,3,3)-Trimethylbicyclo[2.2.1]hept-2-yl)-4-fluorophenyl Sulfonamide
References
ReferencesRishton, G.M., et al. 2000. J. Med. Chem. 43, 2297.
Product Information
CAS number287196-57-0
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₆H₂₂FNO₂S
Chemical formulaC₁₆H₂₂FNO₂S
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetAβ₄₂ production
Primary Target IC<sub>50</sub>1.8 µM against Aβ42 production
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze at (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
565763-5MGCN 04055977267723

Documentation

γ-Secretase Inhibitor VI - CAS 287196-57-0 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

γ-Secretase Inhibitor VI - CAS 287196-57-0 - Calbiochem Certificates of Analysis

TitleLot Number
565763

References

Reference overview
Rishton, G.M., et al. 2000. J. Med. Chem. 43, 2297.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision04-April-2011 RFH
Synonyms1-(S)-endo-N-(1,3,3)-Trimethylbicyclo[2.2.1]hept-2-yl)-4-fluorophenyl Sulfonamide
DescriptionA potent, cell-permeable inhibitor of γ-secretase that blocks the formation of Aβ42 (IC50 = 1.8 µM). Treatment of HEK293 cells with γ-secretase inhibitor VI results in an increase in β-secretase-cleaved, APP fragments and secreted APPSα, but no change in secreted APPSβ, indicating a specific inhibition of γ-secretase activity.
FormWhite solid
CAS number287196-57-0
Chemical formulaC₁₆H₂₂FNO₂S
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (200 mg/ml)
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze at (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesRishton, G.M., et al. 2000. J. Med. Chem. 43, 2297.