565770 Sigma-Aldrichγ-Secretase Inhibitor IX - CAS 208255-80-5 - Calbiochem
Gamma-Secretase Inhibitor IX - CAS 208255-80-5, is a cell-permeable inhibitor of γ-secretase (Aβtotal IC₅₀ = 115 nM, Aβ42 IC₅₀ = 200 nM).
More>> Gamma-Secretase Inhibitor IX - CAS 208255-80-5, is a cell-permeable inhibitor of γ-secretase (Aβtotal IC₅₀ = 115 nM, Aβ42 IC₅₀ = 200 nM). Less<<Synonyms: DAPT, N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-Butyl Ester
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Overview
Key Spec Table
CAS # | Empirical Formula |
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208255-80-5 | C₂₃H₂₆F₂N₂O₄ |
Products
Catalogue Number | Packaging | Qty/Pack | |
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565770-10MGCN | Plastic ampoule | 10 mg | |
565770-5MGCN | Glass bottle | 5 mg |
Description | |
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Overview | A cell-permeable dipeptide that suppresses Aβ production by blocking γ-secretase (Aβtotal IC50 = 115 nM, Aβ42 IC50 = 200 nM). Prevents Aβ34 generation in murine N2a cells and hAPP/hBACE-1 transfected human HEK 293 cells. Reported to be functionally active in both HEK 293 cells and neuronal cultures without affecting the secretion of amyloid-β precursor protein (APP). Also shown to lower Aβ levels acutely in APP-transgenic mice. Reported to reduce extracellular Aβ plaques and intracellular Aβ accumulation in 3xTgAD transgenic mice. A 25 mM (5 mg/462 µl) solution of γ-Secretase Inhibitor IX (Cat. No. 565784) in DMSO is also available. |
Catalogue Number | 565770 |
Brand Family | Calbiochem® |
Synonyms | DAPT, N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-Butyl Ester |
Product Information | |
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CAS number | 208255-80-5 |
ATP Competitive | N |
Form | Lyophilized |
Hill Formula | C₂₃H₂₆F₂N₂O₄ |
Chemical formula | C₂₃H₂₆F₂N₂O₄ |
Reversible | N |
Structure formula Image | |
Quality Level | MQ100 |
Biological Information | |
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Primary Target | Aβtotal |
Primary Target IC<sub>50</sub> | 115 nM suppressing Aβtotal production; 200 nM suppressing Aβ42 production |
Purity | ≥98% by HPLC |
Physicochemical Information | |
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Cell permeable | Y |
Packaging Information | |
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Packaged under inert gas | Packaged under inert gas |
Global Trade Item Number | |
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Catalogue Number | GTIN |
565770-10MGCN | 04055977267778 |
565770-5MGCN | 07790788059941 |