219330 Sigma-Aldrichβ-Catenin/Tcf Inhibitor, FH535 - CAS 108409-83-2 - Calbiochem
The β-Catenin/Tcf Inhibitor, FH535, also referenced under CAS 108409-83-2, controls the biological activity of β-Catenin/Tcf. This small molecule/inhibitor is primarily used for Cell Signaling applications.
More>> The β-Catenin/Tcf Inhibitor, FH535, also referenced under CAS 108409-83-2, controls the biological activity of β-Catenin/Tcf. This small molecule/inhibitor is primarily used for Cell Signaling applications. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: Wnt Pathway Inhibitor IX, N-(2-Methyl-4-nitro)-2,4-dichlorosulfonamide
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Overview
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Key Spec Table
| CAS # | Empirical Formula |
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| 108409-83-2 | C₁₃H₁₀Cl₂N₂O₄S |
Products
| Catalogue Number | Packaging | Qty/Pack | |
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| 219330-10MGCN | Plastic ampoule | 10 mg |
| Description | |
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| Overview | A cell-permeable sulfonamide compound that acts as a dual pathway inhibitor against Wnt/β-catenin (≥80% inhibition at 15 µM in β-catenin/Tcf-dependent cellular reporter assays) and PPARγ/δ (≥30% inhibition at 0.5 µM in PPRE cellular reporter assays) signalings. Although both FH535 and the structurally similar PPARγ-selective inhibitor GW9662 (Cat. No. 370700) inhibit coactivator/PPAR binding, only FH535 blocks β-catenin/PPARγ interaction and the antagonistic activity of FH535 does not involve the covalent modification of or non-covalent interaction with the PPAR ligand-binding site cystein residue that is crucial for GW9662 action. |
| Catalogue Number | 219330 |
| Brand Family | Calbiochem® |
| Synonyms | Wnt Pathway Inhibitor IX, N-(2-Methyl-4-nitro)-2,4-dichlorosulfonamide |
| References | |
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| References | Handeli, S., and Simon, J.A. 2008. Mol. Cancer Ther. 7, 521. |
| Product Information | |
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| CAS number | 108409-83-2 |
| Form | Yellow solid |
| Hill Formula | C₁₃H₁₀Cl₂N₂O₄S |
| Chemical formula | C₁₃H₁₀Cl₂N₂O₄S |
| Structure formula Image | |
| Quality Level | MQ100 |
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| Purity | ≥99% by HPLC |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 219330-10MGCN | 04055977202090 |
Documentation
β-Catenin/Tcf Inhibitor, FH535 - CAS 108409-83-2 - Calbiochem SDS
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β-Catenin/Tcf Inhibitor, FH535 - CAS 108409-83-2 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 219330 |
References
| Reference overview |
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| Handeli, S., and Simon, J.A. 2008. Mol. Cancer Ther. 7, 521. |