Chymotrypsin Substrate II, Fluorogenic - CAS 88467-45-2 - Calbiochem (Cyprus)
- Document Type:
- SDS
- Product Catalog Number:
- 230914
- Product Catalog Name:
- Chymotrypsin Substrate II, Fluorogenic - CAS 88467-45-2 - Calbiochem
818754
105 Results
Gelişmiş Arama
Showing
Sonuçlarınızı Daraltın Use the filters below to refine your search
SourceType
-
-
Color Card 1.18754
- Document Type:
- User Guide
- Product Catalog Number:
- 118754
- Product Catalog Name:
- Chlorine Dioxide Test
-
User Guide (IFU) - 1.18754
- Document Type:
- User Guide
- Product Catalog Number:
- 118754
- Product Catalog Name:
- Chlorine Dioxide Test
-
Anti-Mouse Collagen Type I - 3436168
- Document Type:
- Certificate of Analysis
- Lot Number:
- 3436168
- Product Catalog Number:
- AB765P
- Product Catalog Name:
- Anti-Mouse Collagen Type I Antibody
-
Pelicon 2 Mini Cassette C8EA74567
- Document Type:
- Certificate of Quality
- Lot Number:
- C8EA74567
- Product Catalog Number:
- P2PLBCC01
- Product Catalog Name:
- Pellicon 2 Mini Ultrafiltration Module PLBC C 0.1 m2
-
Certificate of Analysis VW3517 8184
- Document Type:
- Certificate of Analysis
- Lot Number:
- 8184
- Product Catalog Number:
- VW3517
-
Certificate of Analysis 444288_4188754
- Document Type:
- Certificate of Analysis
- Lot Number:
- 4188754
- Product Catalog Number:
- 444288
- Product Catalog Name:
- MMP-2 Inhibitor III - CAS 704888-90-4 - Calbiochem
-
Brain-specific expression of N-acetylglucosaminyltransferase IX (GnT-IX) is regulated by epigenetic histone modifications.
- It is well known that biosynthesis of glycans takes place in organ- and tissue-specific manners and glycan expression is controlled by various factors including glycosyltransferases. The expression mechanism of glycosyltransferases, however, is poorly understood. Here we investigated the expression mechanism of a brain-specific glycosyltransferase, GnT-IX (N-acetylglucosaminyltransferase IX, also designated as GnT-Vb), which synthesizes branched O-mannose glycan. Using an epigenetic approach, we revealed that the genomic region around the transcriptional start site of the GnT-IX gene was highly associated with active chromatin histone marks in a neural cell-specific manner, indicating that brain-specific GnT-IX expression is under control of an epigenetic "histone code." By EMSA and ChIP analyses we identified two regulatory proteins, NeuroD1 and CTCF that bind to and activate the GnT-IX promoter. We also revealed that GnT-IX expression was suppressed in CTCF- and NeuroD1-depleted cells, indicating that a NeuroD1- and CTCF-dependent epigenetic mechanism governs brain-specific GnT-IX expression. Several other neural glycosyltransferase genes are also found to be regulated by epigenetic histone modifications. This is the first report demonstrating a molecular mechanism at the chromatin level underlying tissue-specific glycan expression.
- Document Type:
- Reference
- Product Catalog Number:
- Multiple
- Product Catalog Name:
- Multiple
-
Certificate of Analysis VW3205 8184
- Document Type:
- Certificate of Analysis
- Lot Number:
- 8184
- Product Catalog Number:
- VW3205
-
Certificate of Analysis VW3637 8184
- Document Type:
- Certificate of Analysis
- Lot Number:
- 8184
- Product Catalog Number:
- VW3637