182015
Cyclo(Arg-Gly-Asp-D-Phe-Val)
Potent inhibitor of cell adhesion.
Synonym(s):
Cyclo(Arg-Gly-Asp-D-Phe-Val), RGDFV Peptide, Cyclic
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About This Item
Empirical Formula (Hill Notation):
C26H38N8O7
CAS Number:
Molecular Weight:
574.63
MDL number:
NACRES:
NA.77
UNSPSC Code:
12352202
Product Name
Cyclo(Arg-Gly-Asp-D-Phe-Val), Potent inhibitor of cell adhesion.
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
color
white
solubility
1 N acetic acid: 5 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
Related Categories
Biochem/physiol Actions
Cell permeable: no
Primary Target
inhibits tumor cell adhesion to laminin and vitronectin substrates
inhibits tumor cell adhesion to laminin and vitronectin substrates
Product does not compete with ATP.
Reversible: no
Disclaimer
Toxicity: Standard Handling (A)
General description
Potent inhibitor of cell adhesion. Inhibits tumor cell adhesion to laminin and vitronectin substrates. In vivo investigations in rats showed it to be useful in the amelioration of ischemic acute renal failure in rats. Also inhibits tubular obstruction by preventing cell-cell adhesion. Inhibits the redistribution of c-Src into focal adhesions, thereby leading to impaired MAP Kinase activation.
Other Notes
Shono, T., et al. 2001. Exp. Cell Res.268, 169.
Matsuno, H., et al. 1994. Circulation 90, 2203.
Noiri, E., et al. 1994. Kidney Int. 46, 1050.
Gurrath, M., et al. 1992. Eur. J. Biochem. 210, 911.
Matsuno, H., et al. 1994. Circulation 90, 2203.
Noiri, E., et al. 1994. Kidney Int. 46, 1050.
Gurrath, M., et al. 1992. Eur. J. Biochem. 210, 911.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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