681671 Sigma-AldrichWnt Antagonist II, IWP-2 - CAS 686770-61-6 - Calbiochem
Wnt Antagonist II, IWP-2, CAS 686770-61-6, is a cell-permeable inhibitor of Wnt processing and secretion. Selectively blocks PORCN, a membrane-bound O-acyltransferase, & inhibits Wnt palmitoylation.
More>> Wnt Antagonist II, IWP-2, CAS 686770-61-6, is a cell-permeable inhibitor of Wnt processing and secretion. Selectively blocks PORCN, a membrane-bound O-acyltransferase, & inhibits Wnt palmitoylation. Less<<Synonyms: Wnt Pathway Inhibitor II, Inhibitor of Wnt Production-2, Porcn Inhibitor I
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Overview
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Key Spec Table
CAS # | Empirical Formula |
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686770-61-6 | C₂₂H₁₈N₄O₂S₃ |
Pricing & Availability
Catalogue Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
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681671-10MG |
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Plastic ampoule | 10 mg |
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Description | |
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Overview | A cell-permeable benzothiazolyl-acetamide compound that inhibits the cellular Wnt processing and secretion via selective blockage of MBOAT (membrane-bound O-acyltranferase) family member Porcn- (Porcupine) mediated Wnt palmitoylation. IWP-2 does not affect Wnt/β-catenin signaling pathway in general and, unlike IWR-1-endo (Cat. No. 681669), displays no effect against Wnt-stimulated cellular responses. Also available as a 10 mM solution in DMSO (Cat. No. 506072). |
Catalogue Number | 681671 |
Brand Family | Calbiochem® |
Synonyms | Wnt Pathway Inhibitor II, Inhibitor of Wnt Production-2, Porcn Inhibitor I |
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References | Chen, B., et al. 2009. Nature Chem. Biol. 5, 100. |
Product Information | |
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CAS number | 686770-61-6 |
Form | Off-white solid |
Hill Formula | C₂₂H₁₈N₄O₂S₃ |
Chemical formula | C₂₂H₁₈N₄O₂S₃ |
Quality Level | MQ100 |
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Purity | ≥97% by HPLC |
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Packaged under inert gas | Packaged under inert gas |
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Specifications |
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Global Trade Item Number | |
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Catalogue Number | GTIN |
681671-10MG | 04055977225198 |
Documentation
Wnt Antagonist II, IWP-2 - CAS 686770-61-6 - Calbiochem MSDS
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Wnt Antagonist II, IWP-2 - CAS 686770-61-6 - Calbiochem Certificates of Analysis
Title | Lot Number |
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681671 |
References
Reference overview |
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Chen, B., et al. 2009. Nature Chem. Biol. 5, 100. |