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530961 TAZ Activator, IBS008738 - CAS 385425-03-6 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
385425-03-6C₂₂H₂₂N₄O₂

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      Glass bottle 5 mg
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      Description
      OverviewA benzoylimidazole derivative that acts as a Transcriptional co-activator with PDZ-binding motif (TAZ) Activator by stabilizing TAZ and increases unphosphorylated TAZ. Up-regulates TAZ-dependent MyoD-dependent gene transcription at 10 µM and competes with myostatin in C2C12 cells. Shown to enhance myogenesis most effectively when applied for the first 24 hours under the differentiation condition. Facilitates muscle repair in cardiotoxin-induced muscle injury and prevents dexamethasone-induced muscle atrophy.

      Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
      Catalogue Number530961
      Brand Family Calbiochem®
      Synonyms(4-((morpholinomethylene)amino)-1-(p-tolyl)-1H-imidazol-5-yl)(phenyl)methanone, Transcriptional Co-activator with PDZ-binding Motif (TAZ) Activator, WWTR1 Activator
      References
      ReferencesYang, Z., et al. 2014. Mol. Cell. Biol. 34, 1607.
      Product Information
      CAS number385425-03-6
      FormYellow solid
      Hill FormulaC₂₂H₂₂N₄O₂
      Chemical formulaC₂₂H₂₂N₄O₂
      ReversibleY
      Quality LevelMQ100
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      5.30961.0001 04055977283136