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553210 Rapamycin - CAS 53123-88-9 - Calbiochem

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Rapamycin - CAS 53123-88-9 - Calbiochem: Malzeme Güvenlik Bilgi Formu (MSDS) veya SDS, Analiz Sertifikası (COA) ve Kalite Uygunluk Sertifikası (COQ), dosyalar, broşürler ve diğer dokümanlar.

Synonyms: mTOR Inhibitor I

Primary Target: Mammalian target of rapamycin (mTOR)
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553210
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
53123-88-9C₅₁H₇₉NO₁₃

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      553210-10MG
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          553210-1MG
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              553210-5MG
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                  Description
                  OverviewAnti-fungal and immunosuppressant. Selectively inhibits the mammalian target of rapamycin (mTOR) and blocks the subsequent activation of p70 S6 kinase (IC50 = 50 pM). Specifically inhibits mTORC1, but mTORC2 that phosphorylates Akt at Ser473 appears to be insensitive to rapamycin. Prevents the translational activation of IGF-II. Also prevents resting T-cells from entering the cell cycle, but does not directly arrest cell cycle progression. Shown to inhibit later signaling events, such as p110Rb phosphorylation, p34cdc2 kinase activation, and cyclin A synthesis. Exhibits strong binding to FK-506 binding proteins. Also reported to induce apoptosis in a murine B-cell line, to inhibit lymphokine-induced cell proliferation at the G1 phase, and to irreversibly arrest Saccharomyces cerevisiae cells in the G1 phase. A 5 mM (500 µg/109 µl) solution of Rapamycin (Cat. No. 553211) in DMSO and a 10 mM (1 mg/109 µl) solution of Rapamycin (Cat. No. 553212) in EtOH is also available.
                  Catalogue Number553210
                  Brand Family Calbiochem®
                  SynonymsmTOR Inhibitor I
                  References
                  ReferencesChen, T., et al. 2011. Aging Cell. 10, 908.
                  Powell, D.J., et al. 2003. Mol. cell Biol. 23, 7794.
                  Braun, W., et al. 1995. FASEB J. 9, 63.
                  Nielsen, F.C., et al. 1995. Nature 377, 358.
                  Aagaard-Tillery, K.M. and Jelinek, D.F. 1994. Cell. Immunol. 156, 493.
                  Gottschalk, A.R., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 7350.
                  Morice, W.G., et al. 1993. J. Biol. Chem. 268, 3734.
                  Terada, N., et al. 1993. J. Biol. Chem. 268, 12062.
                  Kuo, J., et al. 1992. Nature 358, 70.
                  Price, D.J., et al. 1992. Science 257, 973.
                  Heitman, J., et al. 1991. Science 253, 905.
                  Kay, J.E., et al. 1991. Immunology 72, 544.
                  Schreiber, S.L. 1991. Science 251, 283.
                  Bierer, B.E., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 9231.
                  Dumont, F.J., et al. 1990. J. Immunol. 144, 251.
                  Product Information
                  CAS number53123-88-9
                  ATP CompetitiveN
                  FormClear film
                  Hill FormulaC₅₁H₇₉NO₁₃
                  Chemical formulaC₅₁H₇₉NO₁₃
                  ReversibleN
                  Structure formula ImageStructure formula Image
                  Quality LevelMQ200
                  Applications
                  Biological Information
                  Primary TargetMammalian target of rapamycin (mTOR)
                  Primary Target IC<sub>50</sub>50 pM against p70 S6 kinase
                  Purity≥99% by HPLC
                  Physicochemical Information
                  Cell permeableN
                  Dimensions
                  Materials Information
                  Toxicological Information
                  Safety Information according to GHS
                  RTECSVE6250000
                  Safety Information
                  Product Usage Statements
                  Storage and Shipping Information
                  Ship Code Ambient Temperature Only
                  Toxicity Standard Handling
                  Storage -20°C
                  Do not freeze Ok to freeze
                  Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
                  Packaging Information
                  Transport Information
                  Supplemental Information
                  Specifications
                  Global Trade Item Number
                  Catalogue Number GTIN
                  553210-100UG 04055977193510
                  553210-10MG 07790788060305
                  553210-1MG 04055977193480
                  553210-5MG 04055977193534

                  Documentation

                  Rapamycin - CAS 53123-88-9 - Calbiochem MSDS

                  Title

                  Safety Data Sheet (SDS) 

                  Rapamycin - CAS 53123-88-9 - Calbiochem Certificates of Analysis

                  TitleLot Number
                  553210

                  References

                  Reference overview
                  Chen, T., et al. 2011. Aging Cell. 10, 908.
                  Powell, D.J., et al. 2003. Mol. cell Biol. 23, 7794.
                  Braun, W., et al. 1995. FASEB J. 9, 63.
                  Nielsen, F.C., et al. 1995. Nature 377, 358.
                  Aagaard-Tillery, K.M. and Jelinek, D.F. 1994. Cell. Immunol. 156, 493.
                  Gottschalk, A.R., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 7350.
                  Morice, W.G., et al. 1993. J. Biol. Chem. 268, 3734.
                  Terada, N., et al. 1993. J. Biol. Chem. 268, 12062.
                  Kuo, J., et al. 1992. Nature 358, 70.
                  Price, D.J., et al. 1992. Science 257, 973.
                  Heitman, J., et al. 1991. Science 253, 905.
                  Kay, J.E., et al. 1991. Immunology 72, 544.
                  Schreiber, S.L. 1991. Science 251, 283.
                  Bierer, B.E., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 9231.
                  Dumont, F.J., et al. 1990. J. Immunol. 144, 251.

                  Brochure

                  Title
                  Bulk Product Guide
                  Caspases and other Apoptosis Related Tools Brochure

                  Data Sheet

                  Title
                  Reprogramming Cell Fate and Function Novel Strategies for iPSC Generation, Characterization, and Differentiation

                  Posters

                  Title
                  Human Kinome & InhibitorSelect™ Libraries

                  Citations

                  Title
                • Chen, T., et al. 2011. Aging Cell. 10, 908.
                • Yu, YL., et al. 2005. Journal of Biological Chemistry 280, 29533.
                • Vega, R.B., et al. 2004. Molecular and Cellular Biology 24, 8374.
                • Liao, X., et al. 2003. Endocrinology 144, 1656.
                  		•
                  Data Sheet

                  Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

                  Revision11-September-2014 JSW
                  SynonymsmTOR Inhibitor I
                  DescriptionSelectively inhibits the mammalian target of rapamycin (mTOR) and blocks the subsequent activation of p70 S6 kinase (IC50 = 50 pM). Specifically inhibits mTORC1, but mTORC2 that phosphorylates Akt at Ser473 appears to be insensitive to rapamycin. Prevents the translational activation of IGF-II. Also prevents resting T-cells from entering the cell cycle, but does not directly arrest cell cycle progression. Shown to inhibit later signaling events, such as p110Rb phosphorylation, p34cdc2 kinase activation, and cyclin A synthesis. Exhibits strong binding to FK-506 binding proteins. Also reported to induce apoptosis in a murine B-cell line, to inhibit lymphokine-induced cell proliferation at the G1 phase, and to irreversibly arrest Saccharomyces cerevisiae cells in the G1 phase.
                  FormClear film
                  CAS number53123-88-9
                  RTECSVE6250000
                  Chemical formulaC₅₁H₇₉NO₁₃
                  Structure formulaStructure formula
                  Purity≥99% by HPLC
                  SolubilityDMSO (200 mg/ml) or Ethanol (50 mg/ml)
                  Storage -20°C
                  Do Not Freeze Ok to freeze
                  Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
                  Toxicity Standard Handling
                  Merck USA index14, 8114
                  ReferencesChen, T., et al. 2011. Aging Cell. 10, 908.
                  Powell, D.J., et al. 2003. Mol. cell Biol. 23, 7794.
                  Braun, W., et al. 1995. FASEB J. 9, 63.
                  Nielsen, F.C., et al. 1995. Nature 377, 358.
                  Aagaard-Tillery, K.M. and Jelinek, D.F. 1994. Cell. Immunol. 156, 493.
                  Gottschalk, A.R., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 7350.
                  Morice, W.G., et al. 1993. J. Biol. Chem. 268, 3734.
                  Terada, N., et al. 1993. J. Biol. Chem. 268, 12062.
                  Kuo, J., et al. 1992. Nature 358, 70.
                  Price, D.J., et al. 1992. Science 257, 973.
                  Heitman, J., et al. 1991. Science 253, 905.
                  Kay, J.E., et al. 1991. Immunology 72, 544.
                  Schreiber, S.L. 1991. Science 251, 283.
                  Bierer, B.E., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 9231.
                  Dumont, F.J., et al. 1990. J. Immunol. 144, 251.
                  Citation
                • Chen, T., et al. 2011. Aging Cell. 10, 908.
                • Yu, YL., et al. 2005. Journal of Biological Chemistry 280, 29533.
                • Vega, R.B., et al. 2004. Molecular and Cellular Biology 24, 8374.
                • Liao, X., et al. 2003. Endocrinology 144, 1656.
                  		•