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Merck

526520

PIM1 Inhibitor II

Synonym(s):

PIM1 Inhibitor II, 3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone, 2-Hydroxy-3-cyano-4-phenyl-6-(3-bromo-6-hydroxyphenyl)pyridine

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About This Item

Empirical Formula (Hill Notation):
C18H11BrN2O2
CAS Number:
491871-58-0
Molecular Weight:
367.20
UNSPSC Code:
12352200

Key Documents

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assay

≥90% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

yellow

solubility

DMSO: 10 mg/mL

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

General description

A pyridone compound that acts as an ATP-competitive inhibitor of PIM1 kinase (IC50 = 50 nM) with excellent selectivity over PIM2 and MEK1/2 (IC50 >20 µM).

This product has been discontinued.



A pyridone compound that acts as an ATP-competitive inhibitor of PIM1 kinase (IC50 = 50 nM) with excellent selectivity over PIM2 and MEK1/2 (IC50 >20 µM).

Other Notes

Cheney, I. W., et al. 2007. Bioorg. Med. Chem. Lett.17, 1679.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Biochem/physiol Actions

Cell permeable: no
Primary Target
PIM1
Product competes with ATP.
Reversible: no
Target IC50: 50 nM against PIM1 kinase

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

10-13 - German Storage Class 10 to 13

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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