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494128
Sigma-AldrichOchratoxin A - CAS 303-47-9 - Calbiochem
Ochratoxin A (OTA) is a mycotoxin that acts through mechanisms such as the inhibition of protein synthesis, and may also be mediated by organic anion transporters (OATs).
More>>Ochratoxin A (OTA) is a mycotoxin that acts through mechanisms such as the inhibition of protein synthesis, and may also be mediated by organic anion transporters (OATs). Less<<
Ochratoxin A - CAS 303-47-9 - Calbiochem: Malzeme Güvenlik Bilgi Formu (MSDS) veya SDS, Analiz Sertifikası (COA) ve Kalite Uygunluk Sertifikası (COQ), dosyalar, broşürler ve diğer dokümanlar.
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Description
Overview
Ochratoxin A (OTA) is a mycotoxin that acts through mechanisms such as the inhibition of protein synthesis, and may also be mediated by organic anion transporters (OATs). OTA is indicated to play a role in down-regulating the expression of protective enzymes against oxidative stress. It is known to accumulate in several tissues of the body but is primarily localized in the kidney where it impairs proximal tubular functions, and thereby causes nephrotoxicity, glucosuria, enzymuria, and a decrease in the transport of para-aminohippuric acid (PAH). It also acts as an immunosuppressant and as a potent teratogen and carcinogen.
Catalogue Number
494128
Brand Family
Calbiochem®
Synonyms
OTA, Ochratoxin A, Aspergillus ochraceus
References
References
Anzai, N., et al. 2010. Toxins2, 1381. Chopra, M., et al. 2010. Cell Biol. Toxicol.26, 239. Luhe, A., et al. 2002. Tox. Sci.73, 315. Dirheimer, G., et al. 1991. IARC Swci Publ.115, 171.
Very toxic if swallowed. Irritating to skin. May impair fertility. May cause harm to the unborn child.
S Phrase
S: 24/25-36/37/39-45
Avoid contact with skin and eyes. Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code
Ambient Temperature Only
Toxicity
Highly Toxic & Carcinogenic / Teratogenic
Hazardous Materials Attention:
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage
+2°C to +8°C
Protect from Light
Protect from light
Do not freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Ochratoxin A - CAS 303-47-9 - Calbiochem Certificates of Analysis
Title
Lot Number
494128
References
Reference overview
Anzai, N., et al. 2010. Toxins2, 1381. Chopra, M., et al. 2010. Cell Biol. Toxicol.26, 239. Luhe, A., et al. 2002. Tox. Sci.73, 315. Dirheimer, G., et al. 1991. IARC Swci Publ.115, 171.
Data Sheet
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
11-October-2016 JSW
Synonyms
OTA, Ochratoxin A, Aspergillus ochraceus
Description
Ochratoxin A (OTA) is a mycotoxin that acts through mechanisms such as the inhibition of protein synthesis, and may also be mediated by organic anion transporters (OATs). OTA is indicated to play a role in down-regulating the expression of protective enzymes against oxidative stress. It is known to accumulate in several tissues of the body but is primarily localized in the kidney where it impairs proximal tubular functions, and thereby causes nephrotoxicity, glucosuria, enzymuria, and a decrease in the transport of para-aminohippuric acid (PAH). It also acts as an immunosuppressant and as a potent teratogen and carcinogen.
Form
Off-white powder
Intert gas (Yes/No)
Packaged under inert gas
CAS number
303-47-9
Chemical formula
C₂₀H₁₈ClNO₆
Structure formula
Purity
≥97% by HPLC
Solubility
DMSO (50 mg/ml; nearly colorless solution)
Storage
Protect from light
+2°C to +8°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity
Highly Toxic & Carcinogenic / Teratogenic
References
Anzai, N., et al. 2010. Toxins2, 1381. Chopra, M., et al. 2010. Cell Biol. Toxicol.26, 239. Luhe, A., et al. 2002. Tox. Sci.73, 315. Dirheimer, G., et al. 1991. IARC Swci Publ.115, 171.
