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538384 NCK/PAK Blocking Peptide

NCK/PAK Blocking Peptide: Malzeme Güvenlik Bilgi Formu (MSDS) veya SDS, Analiz Sertifikası (COA) ve Kalite Uygunluk Sertifikası (COQ), dosyalar, broşürler ve diğer dokümanlar.

Synonyms: TAT-PAK peptide, NCK blocking peptide

Primary Target: NCK
538384
  
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      Overview

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₁₂₆H₂₂₁N₅₁O₃₂S₂·11TFA·7H2O
      Description
      OverviewA cell-permeable synthetic peptide derived from the proline-rich region near the N-terminal of p21 activated kinase1 (PAK1) and fused with HIV TAT. Shown to selectively binds to the non-catalytic region of tyrosine kinase adaptor protein (NCK) and disrupts the cellular transport and localization of PAK. Shown to specifically inhibit endothelial cell migration and contractility (IC50 = 2 µM) and block bFGF-induced angiogenesis in a chick chorioallantoic membrane (CAM) assay. Does not exhibit any deleterious effects on endothelial cell survival and growth.

      Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
      Catalogue Number538384
      Brand Family Calbiochem®
      SynonymsTAT-PAK peptide, NCK blocking peptide
      References
      ReferencesChen, J., et al. 2015, Sci. Signal. 8, 365.
      Kiosses, W., et al. 2002, Circ. Res. 90, 697.
      Product Information
      FormOff-white solid
      FormulationSupplied as TFA salt.
      Hill FormulaC₁₂₆H₂₂₁N₅₁O₃₂S₂·11TFA·7H2O
      Chemical formulaC₁₂₆H₂₂₁N₅₁O₃₂S₂·11TFA·7H2O
      Hygroscopic Hygroscopic
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetNCK
      Primary Target IC<sub>50</sub>2 µ
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceH2N-YGRKKRRQRRRGKPPAPPMRNTSTM-C02H
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      538384 0

      Documentation

      NCK/PAK Blocking Peptide MSDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Chen, J., et al. 2015, Sci. Signal. 8, 365.
      Kiosses, W., et al. 2002, Circ. Res. 90, 697.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision24-October-2017
      SynonymsTAT-PAK peptide, NCK blocking peptide
      DescriptionA cell-permeable synthetic peptide derived from the proline-rich region near the N-terminal of p21 activated kinase1 (PAK1) and fused with HIV TAT. Shown to selectively binds to the non-catalytic region of tyrosine kinase adaptor protein (NCK) and disrupts the cellular transport and localization of PAK. Shown to specifically inhibit endothelial cell migration and contractility (IC50 = 2 µM) and block bFGF-induced angiogenesis in a chick chorioallantoic membrane (CAM) assay. Does not exhibit any deleterious effects on endothelial cell survival and growth.
      FormOff-white solid
      FormulationSupplied as TFA salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₂₆H₂₂₁N₅₁O₃₂S₂·11TFA·7H2O
      Peptide SequenceH2N-YGRKKRRQRRRGKPPAPPMRNTSTM-C02H
      Purity≥98% by HPLC
      SolubilityH₂O (100 mg/ml)
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesChen, J., et al. 2015, Sci. Signal. 8, 365.
      Kiosses, W., et al. 2002, Circ. Res. 90, 697.