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420336 KB-R7943 - CAS 182004-65-5 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
182004-65-5C₁₆H₁₇N₃O₃S • MeSO₃H

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420336-5MG
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      Description
      OverviewA cell-permeable isothiourea derivative that inhibits the influx/reverse mode of Na+/Ca2+ exchangers (NCX; IC50 = 4.3 µM, 4.7 µM, and 1.4 µM for NCX1,NCX2, and NCX3, respectively) and directly modulates Na+/Mg2+ exchange in a Ca2+-dependent manner. Reported to offer neuronal and cardioprotection. Also inhibits nicotinic acetylcholine receptors and NMDA receptor channels (IC50 < 10 µM).
      Catalogue Number420336
      Brand Family Calbiochem®
      Synonyms2-(2-(4-(4-Nitrobenzyloxy)phenyl)ethyl)isothiourea, methane sulfonate, NMDA Antagonist III
      References
      ReferencesHobai, I.A., and O'Rourke, B. 2004. Expert Opin. Investig. Drugs 13, 653.
      Uetani, T., et al. 2003. J. Biol. Chem. 278, 47491.
      Iwamoto, T., et al. 2001. Mol. Pharmacol. 59, 524.
      Pintado, A.J., et al. 2000. Br. J. Pharmacol. 130, 1893.
      Sobolevsky, A.I., and Khodorov, B.I. 1999. Neuropharmacology 38, 1235.
      Iwamoto, T., et al. 1996. J. Biol. Chem. 271, 22391.
      Watano, T., et al. 1996. Br. J. Pharmacol. 119, 555.
      Product Information
      CAS number182004-65-5
      ATP CompetitiveN
      FormWhite crystalline solid
      Hill FormulaC₁₆H₁₇N₃O₃S • MeSO₃H
      Chemical formulaC₁₆H₁₇N₃O₃S • MeSO₃H
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetNa+/Ca2+ exchangers
      Primary Target IC<sub>50</sub>4.3 µM, 4.7 µM, and 1.4 µM for NCX1,NCX2, and NCX3, respectively
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      420336-5MG 07790788050160