420133 Sigma-AldrichJNK Inhibitor VI, TI-JIP153-163 - Calbiochem
The JNK Inhibitor VI, TI-JIP153-163 controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
More>> The JNK Inhibitor VI, TI-JIP153-163 controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Less<<JNK Inhibitor VI, TI-JIP153-163 - Calbiochem: Malzeme Güvenlik Bilgi Formu (MSDS) veya SDS, Analiz Sertifikası (COA) ve Kalite Uygunluk Sertifikası (COQ), dosyalar, broşürler ve diğer dokümanlar.
Synonyms: H₂N-RPKRPTTLNLF-NH₂, Truncated Inhibitor based on JNK-Interacting Protein 1
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Overview
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Key Spec Table
| Empirical Formula |
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| C₆₁H₁₀₄N₂₀O₁₄ |
| Description | |
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| Overview | This product has been discontinued. A murine JIP-1 JNK-binding domain- (JBD) derived 11-mer peptide that directly interacts with JNK (KD in low µM range) and specifically inhibits JNK kinase activity without inhibitory effects towards ERK or p38. The inhibition is not limited only to JBD-containing substrates and is found to be mixed/non-competitive with respect to ATP. JNK Inhibitor VII, TAT-TI-JIP153-163, Cell-Permeable, is also available (Cat. No. 420134). |
| Catalogue Number | 420133 |
| Brand Family | Calbiochem® |
| Synonyms | H₂N-RPKRPTTLNLF-NH₂, Truncated Inhibitor based on JNK-Interacting Protein 1 |
| References | |
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| References | Barr, R.K., et al. 2004. J. Biol. Chem. 279, 36327. Barr, R.K., et al. 2002. J. Biol. Chem. 277, 10987. |
| Product Information | |
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| ATP Competitive | N |
| Form | Lyophilized |
| Formulation | Supplied as a trifluoroacetate salt. |
| Hill Formula | C₆₁H₁₀₄N₂₀O₁₄ |
| Chemical formula | C₆₁H₁₀₄N₂₀O₁₄ |
| Hygroscopic | Hygroscopic |
| Reversible | N |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | JNK |
| Primary Target IC<sub>50</sub> | KD in low µM range |
| Purity | ≥97% by HPLC |
| Physicochemical Information | |
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| Cell permeable | N |
| Peptide Sequence | H-Arg-Pro-Lys-Arg-Pro-Thr-Thr-Leu-Asn-Leu-Phe-NH₂ |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 420133 | 0 |
Documentation
JNK Inhibitor VI, TI-JIP153-163 - Calbiochem MSDS
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JNK Inhibitor VI, TI-JIP153-163 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 420133 |
References
| Reference overview |
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| Barr, R.K., et al. 2004. J. Biol. Chem. 279, 36327. Barr, R.K., et al. 2002. J. Biol. Chem. 277, 10987. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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