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189826 InSolution™ 5-Aza-2ʹ-Deoxycytidine - CAS 2353-33-5 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
2353-33-5C₈H₁₂N₄O₄

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189826-10MG
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      Glass bottle 10 mg
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      Description
      OverviewA cytosine analog that acts as a DNA methyltransferase inhibitor. Restores caspase-8 and caspase-10 mRNA and protein expression as well as TRAIL (Tumor necrosis factor-Related Apoptosis Inducing Ligand) sensitivity in TRAIL-resistant cell lines. Also enhances apoptosis induced by HDAC (Histone Deacetylase) inhibitors. The solid form of this compound (Cat. No. 189825) is also available.
      Catalogue Number189826
      Brand Family Calbiochem®
      SynonymsDecitabine
      References
      ReferencesEggert, A., et al. 2001. Cancer Res. 61, 1314.
      Takebayashi, S., et al. 2001. Biochem. Biophys. Res. Commun. 288, 921.
      Zhu, W.G., et al. 2001. Cancer Res. 61, 1327.
      Hopkins-Donaldson, S., et al. 2000. Cancer Res. 60, 4315.
      Haaf, T. 1995. Pharmacol. Ther. 65, 19.
      Jones, P.A., and Taylor, S.M. 1980. Cell 20, 85.
      Product Information
      CAS number2353-33-5
      FormLiquid
      FormulationA 100 mM (10 mg/438 µl) solution of 5-Aza-2ʹ-Deoxycytidine (Cat. No. 189825) in DMSO.
      Hill FormulaC₈H₁₂N₄O₄
      Chemical formulaC₈H₁₂N₄O₄
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Purity≥ 98% by HPLC
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Regulatory Review
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      189826-10MG 04055977222050