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401479 IKK-2 Inhibitor, SC-514 - CAS 354812-17-2 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
354812-17-2C₉H₈N₂OS₂

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401479-1MG
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      Description
      OverviewA cell-permeable (thienothienyl)amino-acetamide compound that displays anti-inflammatory properties. Acts as a potent, reversible, ATP-competitive, and highly selective inhibitor of IKK-2 (IC50 = ~ 3-12 µM for IKK-2 homodimer, IKK-1/IKK-2 heterodimer, and IKK-2). Its specificity has been confirmed using a panel of 31 other kinases, including IKK isoforms IKK-1, IKK-i, and TBK-1 (IC50 > 200 µM). Shown to specifically block NF-κB-dependent gene expression, but not MAP kinase pathways, in stimulated synovial fibroblasts RASF. A 25 mM (1 mg/178 µl) solution of IKK-2 Inhibitor, SC-514 (Cat. No. 401485) in DMSO is also available.
      Catalogue Number401479
      Brand Family Calbiochem®
      SynonymsSC-514
      References
      ReferencesBaxter, A., et al. 2004 Bioorg. Med. Chem. Lett. 14, 2817.
      Kishore, N., et al. 2003. J. Biol. Chem. 278, 32861.
      Product Information
      CAS number354812-17-2
      ATP CompetitiveY
      FormPale yellow solid
      Hill FormulaC₉H₈N₂OS₂
      Chemical formulaC₉H₈N₂OS₂
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetIKK-2
      Primary Target IC<sub>50</sub>3-12 µM for IKK-2 homodimer, IKK-1/IKK-2 heterodimer, and IKK-2
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      401479-1MG 07790788055806