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373278 Hh Signaling Antagonist XII, MRT-83 - Calbiochem

Hh Signaling Antagonist XII, MRT-83 - Calbiochem: Malzeme Güvenlik Bilgi Formu (MSDS) veya SDS, Analiz Sertifikası (COA) ve Kalite Uygunluk Sertifikası (COQ), dosyalar, broşürler ve diğer dokümanlar.

Synonyms: N-(2-Methyl-5-(3-(3,4,5-trimethoxybenzoyl)guanidino)phenyl)-(1,1ʹ-biphenyl)-4-carboxamide

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      Overview

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₃₁H₃₀N₄O₅
      Description
      Overview

      This product has been discontinued.



      A cell-permeable acylguanidine compound that is shown to block Hh signaling and act as a potent, reversible and high-affinity Smo (Smoothened) antagonist. Displays 20-60 -fold greater potency than Cyclopamine (Cat. No. 239803) and competitively inhibits bodipy-cyclopamine binding to Smo (IC50 = 4.6 and 14 nM in HEK293-hSMO and HEK293-mSMO cells, respectively). Represses ShhN (N-myristoylated Shh) signaling (IC50 = 15 nM for Gli-dependent luciferase activity in Shh-light2 cells) and SAG-(Cat. Nos. 566660 & 566661) induced C3H10T1/2 cell differentiation (IC50 = 10 nM in an alkaline phosphatase activity assay). Inhibits ShhN (3 nM) and SAG (10 nM)-mediated proliferation of rat cerebellar granule cell precursors (IC50 ~ 3 and 6 nM, respectively).

      Catalogue Number373278
      Brand Family Calbiochem®
      SynonymsN-(2-Methyl-5-(3-(3,4,5-trimethoxybenzoyl)guanidino)phenyl)-(1,1ʹ-biphenyl)-4-carboxamide
      References
      ReferencesRoudaut, H., et al. 2011. Mol. Pharmacol. 79, 453.
      Product Information
      FormYellowish-white solid
      Hill FormulaC₃₁H₃₀N₄O₅
      Chemical formulaC₃₁H₃₀N₄O₅
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      373278 0

      Documentation

      Hh Signaling Antagonist XII, MRT-83 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      Hh Signaling Antagonist XII, MRT-83 - Calbiochem Certificates of Analysis

      TitleLot Number
      373278

      References

      Reference overview
      Roudaut, H., et al. 2011. Mol. Pharmacol. 79, 453.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision31-August-2012 JSW
      SynonymsN-(2-Methyl-5-(3-(3,4,5-trimethoxybenzoyl)guanidino)phenyl)-(1,1ʹ-biphenyl)-4-carboxamide
      DescriptionA cell-permeable acylguanidine compound that is shown to block Hh signaling and act as a potent, reversible and high-affinity Smo (Smoothened) antagonist. Displays 20-60 -fold greater potency than Cyclopamine (Cat. No. 239803) and competitively inhibits bodipy-cyclopamine binding to Smo (IC50 = 4.6 and 14 nM in HEK293-hSMO and HEK293-mSMO cells, respectively). Represses ShhN (N-myristoylated Shh) signaling (IC50 = 15 nM for Gli-dependent luciferase activity in Shh-light2 cells) and SAG-(Cat. Nos. 566660 & 566661) induced C3H10T1/2 cell differentiation (IC50 = 10 nM in an alkaline phosphatase activity assay). Inhibits ShhN (3 nM) and SAG (10 nM)-mediated proliferation of rat cerebellar granule cell precursors (IC50 ~ 3 and 6 nM, respectively).
      FormYellowish-white solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₃₁H₃₀N₄O₅
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesRoudaut, H., et al. 2011. Mol. Pharmacol. 79, 453.