345883 Sigma-AldrichGGTI-298 - CAS 180977-44-0 - Calbiochem
A cell-permeable, prodrug form of the GGTase I inhibitor GGTI-297.
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Synonyms: N-4-[2(R)-Amino-3-mercaptopropyl]amino-2-naphthylbenzoyl-(L)-Leucine methyl ester, TFA
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Overview
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Key Spec Table
| CAS # | Empirical Formula |
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| 180977-44-0 | C₂7H₃3N₃O₃S |
| Description | |
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| Overview | A cell-permeable, prodrug form of the GGTase I inhibitor GGTI-297 (Cat. No. 345882). Inhibits the processing of Rap 1A (IC50 = 3 µM) but has no effect on the processing of H-Ras even at concentrations of 15 µM. Inhibits PDGF-receptor tyrosine phosphorylation. Also arrests cells in the G0/G1 phase of the cell cycle, induces apoptosis, and enhances iNOS induction by IL-1β. |
| Catalogue Number | 345883 |
| Brand Family | Calbiochem® |
| Synonyms | N-4-[2(R)-Amino-3-mercaptopropyl]amino-2-naphthylbenzoyl-(L)-Leucine methyl ester, TFA |
| Product Information | |
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| CAS number | 180977-44-0 |
| ATP Competitive | N |
| Form | White solid |
| Formulation | Supplied as a trifluoroacetate salt. |
| Hill Formula | C₂7H₃3N₃O₃S |
| Chemical formula | C₂7H₃3N₃O₃S |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | Rap1a |
| Primary Target IC<sub>50</sub> | 3 µM against processing of Rap 1A |
| Purity | ≥90% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Toxicological Information |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 345883 | 0 |
Documentation
GGTI-298 - CAS 180977-44-0 - Calbiochem MSDS
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GGTI-298 - CAS 180977-44-0 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 345883 |
References
| Reference overview |
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| Qian, Y., et al. 1998. Bioorg. Med. Chem. 6, 293. Finder, J.D., et al. 1997. J. Biol. Chem. 272, 13484. Miquel, K., et al. 1997. Cancer Res. 57, 1846. Vogt, A., et al. 1997. J. Biol. Chem. 272, 27224. McGuire, T., et al. 1996. J. Biol. Chem. 271, 27402. Vogt, A., et al. 1996. Oncogene 13, 1991. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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