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344216 Formyl Peptide Receptor-Like 1 Agonist, WKYMVm - Calbiochem

The Formyl Peptide Receptor-Like 1 Agonist, WKYMVm controls the biological activity of Formyl Peptide Receptor-Like 1. This small molecule/inhibitor is primarily used for Activators/Inducers applicati

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Formyl Peptide Receptor-Like 1 Agonist, WKYMVm - Calbiochem: Malzeme Güvenlik Bilgi Formu (MSDS) veya SDS, Analiz Sertifikası (COA) ve Kalite Uygunluk Sertifikası (COQ), dosyalar, broşürler ve diğer dokümanlar.

Synonyms: H₂N-WKYMV-D-M-CONH₂, FPRL1 Agonist, WKYMVm

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344216
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344216-5MG
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      Description
      OverviewA potent chemoattractant that enhances leukocyte activity via activation of Formyl Peptide Receptor-Like 1 (FPRL1). Shown to activate phospholipase C-mediated inositol phosphate formation in human U266 myeloma cells (EC50 = 510 pM). Also shown to stimulate inositol phosphate formation in U937 and HL60 cells, but has no effect on a variety of other cell lines (e.g. NIH3T3, PC12, Daudi, Sp2, Jurkat, H9, Molt-4, SupT-1, K562, and RBL-2H3). Stimulates phagocyte chemotaxis and [Ca2+] flux, and is more effective than fMLP (Cat. No. 05-22-2500) in generating superoxide in human neutrophils. Radioiodinatable at the tyrosine residue.
      Catalogue Number344216
      Brand Family Calbiochem®
      SynonymsH₂N-WKYMV-D-M-CONH₂, FPRL1 Agonist, WKYMVm
      References
      ReferencesBae, Y.S., et al. 2004. J. Immunol. 173, 607.
      Bae, Y.S., et al. 2003. Mol. Pharmacol. 64, 841.
      Le, Y., et al. 1999. J. Immunol. 163, 6777.
      Seo, J.K., et al. 1997. J. Immunol. 158, 1895.
      Baek, S.H., et al. 1996. J. Biol. Chem. 271, 8170.
      Product Information
      ATP CompetitiveN
      FormLyophilized
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₄₁H₆₁N₉O₇S₂
      Chemical formulaC₄₁H₆₁N₉O₇S₂
      Hygroscopic Hygroscopic
      ReversibleN
      Quality LevelMQ100
      Biological Information
      Primary TargetFormyl Peptide Receptor-Like 1
      Primary Target IC<sub>50</sub>EC50 = 510 pM in activating phospholipase C-mediated inositol phosphate formation in human U266 myeloma cells
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide SequenceH-Trp-Lys-Tyr-Met-Val-D-Met-CONH₂
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      344216-5MG 04055977215328