Millipore Sigma Vibrant Logo

324414 Dynamin Inhibitor V, 34-2 - CAS 1128165-88-7 - Calbiochem

The Dynamin Inhibitor V, 34-2 controls the biological activity of Dynamin. This small molecule/inhibitor is primarily used for Membrane applications.

Dynamin Inhibitor V, 34-2 - CAS 1128165-88-7 - Calbiochem: Malzeme Güvenlik Bilgi Formu (MSDS) veya SDS, Analiz Sertifikası (COA) ve Kalite Uygunluk Sertifikası (COQ), dosyalar, broşürler ve diğer dokümanlar.

Synonyms: 2-Cyano-N-octyl-3-(1-(3-dimethylaminopropyl)-1H-indol-3-yl)-acrylamide

View Products on Sigmaaldrich.com
324414
View Pricing & Availability

Overview

Key Spec Table

CAS #Empirical Formula
1128165-88-7C₂₅H₃₆N₄O

Pricing & Availability

Catalogue Number AvailabilityPackaging Qty/Pack Price Quantity
324414-10MG
—
Limited Availability Limited Availability
In Stock 
Discontinued
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      		 Glass bottle 10 mg
      Price could not be retrieved
      Minimum Quantity is a multiple of
      Maximum Quantity is
      Upon Order Completion More Information
      You Saved ()
       
      —
      Request Pricing
      		 —
      Add To Favorites
      Description
      OverviewA cell-permeable, allosteric Dynamin inhibitor (IC50 = 6.9 µM and 14 µM for full length Dynamin I and Dynamin II GTPase activity, respectively, in vitro). 10 µM of this compound results in cytokinesis failure at the abscission stage in HeLa cultures, with 82% of cells that enter into mitosis becoming multinucleated, and with 97% resulting in cell death. However, it displays a much reduced effect in NIH3T3 cells at the same concentration. It elicits a dose-dependent reduction in cell growth against SMA-560, SJ-G2, SW480, MCF-7 and A2780 cultures, as being the most sensitive among a panel of other cancer cell lines (GI50 = 4.0–37 µM). It was further shown to be 6-fold more active (IC50 = 5.0 µM) than dynamin mediated receptor mediated endocytosis (RME) in U2OS cells, and 15-fold more active (IC50 = 1.3 µM) than Dynasore (Cat. No. 324410) in another Dynamin I GTPase activity assay.
      Catalogue Number324414
      Brand Family Calbiochem®
      Synonyms2-Cyano-N-octyl-3-(1-(3-dimethylaminopropyl)-1H-indol-3-yl)-acrylamide
      References
      ReferencesChircop, M. et al. 2011. Mol. Cancer Ther. 10, 1553.
      Hill, T.A., et al. 2009. J. Med. Chem. 52, 3762.
      Product Information
      CAS number1128165-88-7
      FormYellow solid
      Hill FormulaC₂₅H₃₆N₄O
      Chemical formulaC₂₅H₃₆N₄O
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Purity≥99% by HPLC
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      324414-10MG 04055977197204