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260010 Demethylasterriquinone B1 - CAS 78860-34-1 - Calbiochem

Demethylasterriquinone B1 - CAS 78860-34-1 - Calbiochem: Malzeme Güvenlik Bilgi Formu (MSDS) veya SDS, Analiz Sertifikası (COA) ve Kalite Uygunluk Sertifikası (COQ), dosyalar, broşürler ve diğer dokümanlar.

Synonyms: 2,5-Dihydroxy-3-[7-(3-methyl-but-2-enyl)-1H-indol-3-yl]-6-[2-(1,1-dimethyl-allyl)-1H-indol-3-yl]-[1,4]benzoquinone, L-783,281, DMAQ-B1, DAQ B1, 2-[2-(1,1-Dimethylallyl)-1H-indol-3-yl]-3,6-dihydroxy-5-[7-(3-methylbut-2-enyl)-1H-indol-3-yl][1,4]benzoquinone

Primary Target: Insulin receptor (IR) tyrosine kinase activity
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      Overview

      Key Spec Table

      CAS #Empirical Formula
      78860-34-1C₃₂H₃₀N₂O₄
      Description
      Overview

      This product has been discontinued.



      A cell-permeable unsymmetrical bis-indolylquinone insulin mimic with anti-diabetic activity in animal models. Selectively stimulates insulin receptor (IR) tyrosine kinase activity (EC50 ~ 6 µM in CHO•IR cells), while showing little effect towards IGF-1R, EGFR, or PDGFR. Also acts as an agonist for the neurotrophin receptors TrkA, B, and C in both cortical neurons and dorsal root ganglion neurons (~ 20 µM). DMAQ-B1 and insulin show differential effects on cellular gene expression profiles and DMAQ-B1 is a more selective agonist than insulin for the IR-mediated activation of PI-3 kinase/Akt pathway.
      Catalogue Number260010
      Brand Family Calbiochem®
      Synonyms2,5-Dihydroxy-3-[7-(3-methyl-but-2-enyl)-1H-indol-3-yl]-6-[2-(1,1-dimethyl-allyl)-1H-indol-3-yl]-[1,4]benzoquinone, L-783,281, DMAQ-B1, DAQ B1, 2-[2-(1,1-Dimethylallyl)-1H-indol-3-yl]-3,6-dihydroxy-5-[7-(3-methylbut-2-enyl)-1H-indol-3-yl][1,4]benzoquinone
      References
      ReferencesWebster, N.J., et al. 2003. Chembiochem 4, 379.
      Pirrung, M.C., et al. 2002. J. Org. Chem. 6, 23.
      Westerlund, J., et al. 2002. Diabetes 51, S50.
      Roper, M.G., et al. 2002. Diabetes 51, S43.
      Air, E.L., et al. 2002. Nat. Med. 8, 179.
      Wilkie, N., et al. 2001. J. Neurochem. 78, 1135.
      Salituro, G.M., et al. 2001. Recent Prog. Horm. Res. 56, 107.
      Liu, K., et al. 2000. J. Med. Chem. 43, 3487.
      Zhang, B., et al. 1999. Science 284, 974.
      Product Information
      CAS number78860-34-1
      ATP CompetitiveN
      FormBluish black solid
      Hill FormulaC₃₂H₃₀N₂O₄
      Chemical formulaC₃₂H₃₀N₂O₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetInsulin receptor (IR) tyrosine kinase activity
      Primary Target IC<sub>50</sub>EC50 ~ 6 µM stimulating insulin receptor (IR) tyrosine kinase activity in CHO•IR cells
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Irritant
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      260010 0