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260905 DNase γ Inhibitor, 6-DTAF

260905
  
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      Overview

      Description
      Overview

      This product has been discontinued.

      We apologize for the inconvenience, but we do not currently have an alternative product.





      A cell-permeable triazinyl-aminofluorescein compound that acts as a potent and selective inhibitor of DNase γ, human (IC50 = 3.2 µM) with minimal effects on DNase I, bovine (Cat. No. 260913; IC50 > 300 µM). Shown to prevent DNase γ-catalyzed apoptotic DNA fragmentation in HeLa-γ cells induced by Staurosporine (Cat. No. 569397) and in rat splenocytes exposed to γ-ray irradiation. Does neither affect PARP cleavage nor CAD (caspase activated DNase)-mediated DNA fragmentation.
      Catalogue Number260905
      Brand Family Calbiochem®
      Synonyms4-(4,6-Dichloro-[1,3,5]-triazin-2-ylamino)-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-benzoic acid, 6-(4,6-Dichlorotriazinyl)aminofluorescein, DR396
      References
      ReferencesOkamoto, M., et al. 2005. Biochem. Biophys. Res. Commun. 327, 76. Sunaga, S., et al. 2004. Biochem. Biophys. Res. Commun. 325, 1292.
      Product Information
      CAS number82169-58-2
      FormYellow solid
      Hill FormulaC₂₃H₁₂Cl₂N₄O₅
      Chemical formulaC₂₃H₁₂Cl₂N₄O₅
      Structure formula ImageStructure formula Image
      Biological Information
      Primary TargetDnase γ, human
      Primary Target IC<sub>50</sub>3.2 µM
      Secondary targetDnase-1,bovine = 300 µM
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      260905 0