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250233 Cytochalasin B, Helminthosporium dematioideum - CAS 14930-96-2 - Calbiochem

Cytochalasin B, Helminthosporium dematioideum - CAS 14930-96-2, is a cell-permeable fungal toxin that inhibits cytoplasmic division by blocking the formation of contractile microfilaments.

Cytochalasin B, Helminthosporium dematioideum - CAS 14930-96-2 - Calbiochem: Malzeme Güvenlik Bilgi Formu (MSDS) veya SDS, Analiz Sertifikası (COA) ve Kalite Uygunluk Sertifikası (COQ), dosyalar, broşürler ve diğer dokümanlar.
Primary Target: Blocking the formation of contractile microfilaments
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250233
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
14930-96-2C₂₉H₃₇NO₅

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250233-5MG
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      Description
      OverviewCell-permeable fungal toxin. Inhibits cytoplasmic division by blocking the formation of contractile microfilaments. Inhibits cell movement and induces nuclear extrusion. Shortens actin filaments by blocking monomer addition at the fast-growing end of polymers. Inhibits glucose transport and platelet aggregation. Blocks adenosine-induced apoptotic body formation without affecting activation of endogenous ADP-ribosylation in leukemia HL-60 cells.
      Catalogue Number250233
      Brand Family Calbiochem®
      References
      ReferencesTanaka, Y., et al. 1994. Exp. Cell Res. 213, 242.
      Theodoropoulos, P.A., et al. 1994. Biochem. Pharmacol. 47, 1875.
      Benya, P.D., and Padilla, S.R. 1993. Exp. Cell Res. 204, 268.
      Cairns, M.T., et al. 1991. J. Biol. Chem. 266, 8176.
      Nowak, D. 1990. Biomed. Biochim. Acta 49, 353.
      Wang, F., et al. 1990. Biochem. Biophys. Res. Commun. 171, 543.
      Edwards, S.W., and Lloyd, D. 1988. FEBS Lett. 227, 39.
      Product Information
      CAS number14930-96-2
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₉H₃₇NO₅
      Chemical formulaC₂₉H₃₇NO₅
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationCytochalasin B, Helminthosporium dematioideum - CAS 14930-96-2, is a cell-permeable fungal toxin that inhibits cytoplasmic division by blocking the formation of contractile microfilaments.
      Biological Information
      Primary TargetBlocking the formation of contractile microfilaments
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSRO0205000
      Safety Information
      R PhraseR: 26/27/28-63

      Very toxic by inhalation, in contact with skin and if swallowed.
      Possible risk of harm to the unborn child.
      S PhraseS: 22-36/37/39-45

      Do not breathe dust.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Highly Toxic & Carcinogenic / Teratogenic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution store in the refrigerator (4°C). Stock solutions are stable for up to 3 months at 4°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      250233-5MG 04055977199147

      Documentation

      Cytochalasin B, Helminthosporium dematioideum - CAS 14930-96-2 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      Cytochalasin B, Helminthosporium dematioideum - CAS 14930-96-2 - Calbiochem Certificates of Analysis

      TitleLot Number
      250233

      References

      Reference overview
      Tanaka, Y., et al. 1994. Exp. Cell Res. 213, 242.
      Theodoropoulos, P.A., et al. 1994. Biochem. Pharmacol. 47, 1875.
      Benya, P.D., and Padilla, S.R. 1993. Exp. Cell Res. 204, 268.
      Cairns, M.T., et al. 1991. J. Biol. Chem. 266, 8176.
      Nowak, D. 1990. Biomed. Biochim. Acta 49, 353.
      Wang, F., et al. 1990. Biochem. Biophys. Res. Commun. 171, 543.
      Edwards, S.W., and Lloyd, D. 1988. FEBS Lett. 227, 39.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision06-April-2009 JSW
      DescriptionCell-permeable fungal toxin. Inhibits cytoplasmic division by blocking the formation of contractile microfilaments. Inhibits cell movement and induces nuclear extrusion. Shortens actin filaments by blocking monomer addition at the fast growing end of polymers. Inhibits glucose transport and platelet aggregation. Blocks adenosine-induced apoptotic body formation without affecting activation of endogenous ADP-ribosylation in leukemia HL-60 cells.
      FormWhite solid
      CAS number14930-96-2
      RTECSRO0205000
      Chemical formulaC₂₉H₃₇NO₅
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (50 mg/ml) or Methanol (20 mg/ml). Poor quality DMSO will cause degradation of the product, so high quality DMSO is recommended.
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution store in the refrigerator (4°C). Stock solutions are stable for up to 3 months at 4°C.
      Toxicity Highly Toxic & Carcinogenic / Teratogenic
      Merck USA index14, 2790
      ReferencesTanaka, Y., et al. 1994. Exp. Cell Res. 213, 242.
      Theodoropoulos, P.A., et al. 1994. Biochem. Pharmacol. 47, 1875.
      Benya, P.D., and Padilla, S.R. 1993. Exp. Cell Res. 204, 268.
      Cairns, M.T., et al. 1991. J. Biol. Chem. 266, 8176.
      Nowak, D. 1990. Biomed. Biochim. Acta 49, 353.
      Wang, F., et al. 1990. Biochem. Biophys. Res. Commun. 171, 543.
      Edwards, S.W., and Lloyd, D. 1988. FEBS Lett. 227, 39.