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219417 Cathepsin Inhibitor II

Cathepsin Inhibitor II: Malzeme Güvenlik Bilgi Formu (MSDS) veya SDS, Analiz Sertifikası (COA) ve Kalite Uygunluk Sertifikası (COQ), dosyalar, broşürler ve diğer dokümanlar.

Synonyms: Z-FG-NHO-BzME

Primary Target: cathepsin B
219417
  
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      Overview

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₂₇H₂₇N₃O₆
      Description
      Overview

      This product has been discontinued.





      Cysteine protease inhibitor. Selectively inhibits cathepsin B (k2/Ki = 6.9 x 103 M-1 sec-1), cathepsin L (k2/Ki = 3.1 x 105 M-1 sec-1), cathepsin S (k2/Ki = 4.3 x 104 M-1 sec-1), and papain (k2/Ki = 1.8 x 103 M-1 sec-1).
      Half-life in buffered solution (pH 5-9) = 27 h (30°C); 300 h (0°C).
      Catalogue Number219417
      Brand Family Calbiochem®
      SynonymsZ-FG-NHO-BzME
      References
      ReferencesDemuth, H.-U., et al. 1996. Biochim. Biophys. Acta 1295, 179.
      Brömme, D., and Demuth, H.-U. 1994. Methods Enzymol. 244, 671.
      Product Information
      FormWhite solid
      Hill FormulaC₂₇H₂₇N₃O₆
      Chemical formulaC₂₇H₂₇N₃O₆
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary Targetcathepsin B
      Primary Target IC<sub>50</sub>k₂/Ki = 6.9 x 10³ M⁻¹ sec⁻¹
      Secondary targetcathepsin L (k₂/Ki = 3.1 x 10⁵ M⁻¹ sec⁻¹), cathepsin S (k₂/Ki = 4.3 x 10⁴ M⁻¹ sec⁻¹), and papain (k₂/Ki = 1.8 x 10³ M⁻¹ sec⁻¹)
      Purity>90% by HPLC
      Physicochemical Information
      Peptide SequenceZ-Phe-Gly-NHO-Bz-pMe
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +15°C to +30°C
      Protect from Light Protect from light
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      219417 0

      Documentation

      Cathepsin Inhibitor II Certificates of Analysis

      TitleLot Number
      219417

      References

      Reference overview
      Demuth, H.-U., et al. 1996. Biochim. Biophys. Acta 1295, 179.
      Brömme, D., and Demuth, H.-U. 1994. Methods Enzymol. 244, 671.

      Brochure

      Title
      Cathepsins and Related Products Technical Bulletin
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision18-July-2011 JSW
      SynonymsZ-FG-NHO-BzME
      DescriptionCysteine protease inhibitor. Selectively inhibits cathepsin B (k2/Ki = 6.9 x 103 M-1 sec-1), cathepsin L (k2/Ki = 3.1 x 105 M-1 sec-1), cathepsin S (k2/Ki = 4.3 x 104 M-1 sec-1), and papain (k2/Ki = 1.8 x 103 M-1 sec-1). Half-life in buffered solution (pH 5-9) = 27 h (30°C); 300 h (0°C).
      FormWhite solid
      Chemical formulaC₂₇H₂₇N₃O₆
      Peptide SequenceZ-Phe-Gly-NHO-Bz-pMe
      Structure formulaStructure formula
      Purity>90% by HPLC
      SolubilityAcetonitrile, DMSO, or Ethanol
      Storage Protect from moisture
      Protect from light
      +15°C to +30°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesDemuth, H.-U., et al. 1996. Biochim. Biophys. Acta 1295, 179.
      Brömme, D., and Demuth, H.-U. 1994. Methods Enzymol. 244, 671.