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AB2991 Anti-p32 Antibody

This Anti-p32 Antibody is validated for use in WB, IC for the detection of p32.

Anti-p32 Antibody: Malzeme Güvenlik Bilgi Formu (MSDS) veya SDS, Analiz Sertifikası (COA) ve Kalite Uygunluk Sertifikası (COQ), dosyalar, broşürler ve diğer dokümanlar.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: C1QBP, C1qBP, GC1QBP, HABP1, SF2P32, SF2p32, gC1Q-R, gC1qR, p32, p33 UniProt Number: Q07021
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AB2991
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWB, ICCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB2991
      DescriptionAnti-p32 Antibody
      Alternate Names
      • C1q globular domain-binding protein
      • GC1q-R protein
      • Glycoprotein gC1qBP
      • Hyaluronan-binding protein 1
      • Mitochondrial matrix protein p32
      • complement component 1, q subcomponent binding protein
      • splicing factor SF2-associated protein
      Background InformationThe p32 protein is a doughnut-shaped trimer that is primarily localized in the mitochondria. It has also been reported to be present at the cell surface and in the nucleus. The role of p32 in mammalian cells is unclear. The yeast p32 homologue has been reported to regulate oxidative phosphorylation, and a link to autophagy has been proposed. Elevated expression of p32 in cancer has also been noted. Additionally, p32 is primarily localized in hypoxic/nutrient-deprived regions within tumors and that, in addition to tumor cells, a tumor-associated macrophage/myeloid cell subpopulation closely linked to tumor lymphatics expresses high levels of p32. The expression of p32 at the cell surface, where it can be targeted with p32-binding antibodies and peptides, adds a second level of tumor specificity to p32 expression. The unique expression pattern of p32 in tumor cells, tumor lymphatics, and tumor-associated macrophages/myeloid cells makes p32 a potential target for the diagnosis and therapy of cancer.
      References
      Product Information
      FormatAffinity Purified
      Control
      • A431 cell lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-p32 Antibody is validated for use in WB, IC for the detection of p32.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      Application NotesImmunocytochemistry Analysis: 1:500 dilution from a previous lot detected p32 in HeLa and A431 cells.
      Biological Information
      ImmunogenCocktail of peptides corresponding to the N-terminus of human and mouse p32.
      EpitopeUnknown
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes p32.
      IsotypeIgG
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe human complement subcomponent C1q associates with C1r and C1s in order to yield the first component of the serum complement system. The protein encoded by this gene is known to bind to the globular heads of C1q molecules and inhibit C1 activation. This protein has also been identified as the p32 subunit of pre-mRNA splicing factor SF2, as well as a hyaluronic acid-binding protein. [provided by RefSeq].
      Gene Symbol
      • C1QBP
      • C1qBP
      • GC1QBP
      • HABP1
      • SF2P32
      • SF2p32
      • gC1Q-R
      • gC1qR
      • p32
      • p33
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Not known. Binds to the globular "heads" of C1Q thus inhibiting C1 activation.

      SUBUNIT STRUCTURE: Interacts with Rubella virus capsid protein.

      SUBCELLULAR LOCATION: Mitochondrion matrix.

      SEQUENCE SIMILARITIES: Belongs to the MAM33 family.

      CAUTION: Was originally thought to be a pre-mRNA splicing factor SF2 p32 subunit and to play a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing.
      Molecular Weight ~ 32 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in A431 cell lysate.

      Western Blot Analysis: 0.5 µg/ml of this antibody detected p32 on 10 µg of A431 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      AB2991 04053252280528