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MABC46 Anti-Atg13 Antibody, clone 2H4.2

This Anti-Atg13 Antibody, clone 2H4.2 is validated for use in Western Blotting, IHC for the detection of Atg13.

Anti-Atg13 Antibody, clone 2H4.2: Malzeme Güvenlik Bilgi Formu (MSDS) veya SDS, Analiz Sertifikası (COA) ve Kalite Uygunluk Sertifikası (COQ), dosyalar, broşürler ve diğer dokümanlar.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: ATG13 UniProt Number: O75143
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MABC46
100 µL  
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      Overview

      Replacement Information

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IHCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABC46
      DescriptionAnti-Atg13 Antibody, clone 2H4.2
      Alternate Names
      • Autophagy-related protein 13
      Background InformationThe autophagy-related protein 13 (Atg13) plays an important role in the formation of autophagosomes. Autophagosomes are formed in response to nutrient deprivation and function as the transport vesicles for organelles, proteins, and protein complexes targeted for lysosomes that digest these cargos to produce energy and nutrients. Atg13 is activated by the mTOR pathway and forms a complex with the FIP200 protein. This complex is involved in enhancing the activity of the ULK1 kinase which is required for the formation of autophagosomes. Atg13/FIP200 faciliates the localization of ULK1 to pre-autophagosomes, and subsequently stabilizes ULK1. Autophagy is an important process in development, growth, and cell differentiation, and disruption of this process may contribute to cancer, aging, and neurodegenerative diseases.
      References
      Product Information
      FormatPurified
      Control
      • Campthothecin treated HeLa cell lysate.
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Atg13 Antibody, clone 2H4.2 is validated for use in Western Blotting, IHC for the detection of Atg13.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesWestern Blot Analysis: A representative lot detected Atg13 in HeLa cell lysate.

      Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Atg13 in normal human substancia nigra tissues.
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to human Atg13.
      Clone2H4.2
      HostMouse
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • ATG13
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~60 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in campthothecin treated HeLa cell lysate.

      Western Blot Analysis: A 1:1,000 dilution of this antibody detected Atg13 in 10 µg of campthothecin treated HeLa cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABC46 04053252522079

      Documentation

      Anti-Atg13 Antibody, clone 2H4.2 MSDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Atg13 Antibody, clone 2H4.2 Certificates of Analysis

      TitleLot Number
      Anti-Atg13, clone 2H4.2 - 2367819 2367819
      Anti-Atg13, clone 2H4.2 - 2379491 2379491
      Anti-Atg13, clone 2H4.2 - 2055306 2055306
      Anti-Atg13, clone 2H4.2 - 2296762 2296762
      Anti-Atg13, clone 2H4.2 - 2328388 2328388
      Anti-Atg13, clone 2H4.2 - 2360590 2360590
      Anti-Atg13, clone 2H4.2 - 3429920 3429920
      Anti-Atg13, clone 2H4.2 - 3488524 3488524
      Anti-Atg13, clone 2H4.2 - Q2009200 Q2009200
      Anti-Atg13, clone 2H4.2 -2489998 2489998
      Show more

      Brochure

      Title
      New Products: Volume 3, 2012

      Newsletters / Publications

      Title
      Autophagy Research Focus

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies