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ABN240 Anti-Amyloid, β 1-40, aβ Antibody

Anti-Amyloid, β 1-40, aβ Antibody is an antibody against Amyloid, β 1-40, aβ for use in Western Blotting, IHC(P), ELISA.

Anti-Amyloid, β 1-40, aβ Antibody: Malzeme Güvenlik Bilgi Formu (MSDS) veya SDS, Analiz Sertifikası (COA) ve Kalite Uygunluk Sertifikası (COQ), dosyalar, broşürler ve diğer dokümanlar.
Research Category: Neuroscience Research Sub-Category: Neurodegenerative Diseases Gene Symbol: APP, A4, AD1 UniProt Number: P05067
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ABN240
100 µL  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IH(P), ELISARbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABN240
      ReplacesAB5737
      DescriptionAnti-Amyloid, β 1-40, aβ Antibody
      Alternate Names
      • Amyloid beta A4 protein
      • ABPP
      • APPI
      • APP
      • Alzheimer disease amyloid protein
      • Cerebral vascular amyloid peptide
      • CVAP
      • PreA4
      • Protease nexin-II
      • PN-II
      • 1.N-APP2.Soluble APP-alpha
      • S-APP-alpha3.Soluble APP-beta
      • S-APP-beta4.C995.Beta-amyloid protein 42
      • Beta-APP426.Beta-amyloid protein 40
      • Beta-APP407.C838.P3(42)9.P3(40)10.C8011.Gamma-secretase C-terminal fragment 59
      • Amyloid intracellular domain 59
      • AICD-59
      • AID(59)
      • Gamma-CTF(59)12.Gamma-secretase C-terminal fragment 57
      • Amyloid intracellular domain 57
      • AICD-57
      • AID(57)
      • Gamma-CTF(57)13.Gamma-secretase C-terminal fragment 50
      • Amyloid intracellular domain 50
      • AICD-50
      • AID(50)
      • Gamma-CTF(50)14.C31
      Background InformationAmyloid β 1-40 is one of several functional peptides (39 to 43 amino acids in length) formed from proteolytic cleavage of the amyloid-beta precursor protein (APP) by the family of secretase enzymes. Although the APP protein is required for a number of biological functions including axonal transport, cell adhesion, and transcription, the amyloid β 1-40 peptide has been studied mostly for its role in neurotoxicity, particularly in the context of Alzheimer’s disease. Previous studies have reported that expression of amyloid β 1-40 increases in Alzheimer’s disease and correlate with the occurrence of aberrant synaptic structure and cognitive dysfunction. These detrimental effects on neural function may be related to aggregation of this peptide (formation of neurite plaques), as neurite plaques been shown to disrupt multiple neurotransmitter systems, and synaptic events such as long-term potentiation.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Human Alzhiemer brain tissue lysate
      PresentationPurified rabbit polyclonal serum in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Amyloid, β 1-40, aβ Antibody is an antibody against Amyloid, β 1-40, aβ for use in Western Blotting, IHC(P), ELISA.
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      • ELISA
      Application NotesImmunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected Amyloid, B 1-40 in human Alzheimer's diseased brain tissue.

      ELISA: A representative lot detected Amyloid, B 1-40 in ELISA (Direct).
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to the P3(40) peptide of human Amyloid, B 1-40.
      EpitopeP3(40) peptide
      HostRabbit
      SpecificityThis antibody recognizes the P3(40) peptide of Amyloid, β 1-40.
      Species Reactivity
      • Human
      Species Reactivity NoteDemonstrated to react with Human. Predicted to react with Mouse, Rat, and Bovine based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • APP
      • A4
      • AD1
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~4 kDa observed. An uncharacterized band appears at ~19 kDa in some lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in human Alzheimer brain tissue lysate.

      Western Blot Analysis: 0.5 µg/mL of this antibody detected Amyloid, B 1-40 on 10 µg of human Alzheimer brain tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABN240 04053252648830

      Documentation

      Anti-Amyloid, β 1-40, aβ Antibody MSDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Amyloid, β 1-40, aβ Antibody Certificates of Analysis

      TitleLot Number
      Anti-Amyloid, 1-40, a - 2262714 2262714
      Anti-Amyloid, #946; 1-40, a#946; - Q2027064 Q2027064
      Anti-Amyloid, β 1-40, aβ 2480958
      Anti-Amyloid, β 1-40, aβ - 3258754 3258754
      Anti-Amyloid, β 1-40, aβ - 3403479 3403479
      Anti-Amyloid, β 1-40, aβ - 3984068 3984068
      Anti-Amyloid, β 1-40, aβ - 4018523 4018523
      Anti-Amyloid, β 1-40, aβ -2652009 2652009
      Anti-Amyloid, β 1-40, aβ -2657491 2657491
      Anti-Amyloid, β 1-40, aβ Polyclonal Antibody 2967247
      Show more

      Newsletters / Publications

      Title
      Research Focus - Volume 2, 2013

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies