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GF164 ANG-1 Protein, Human Recombinant

The Ang-1 protein & Ang-2 protein are secreted ligands which bind with similar affinity to Tie2, a receptor tyrosine kinase with immunoglobulin & epidermal growth factor homology domains expressed on endothelial & early hematopoietic cells.

ANG-1 Protein, Human Recombinant: Malzeme Güvenlik Bilgi Formu (MSDS) veya SDS, Analiz Sertifikası (COA) ve Kalite Uygunluk Sertifikası (COQ), dosyalar, broşürler ve diğer dokümanlar.
UniProt Number: Q15389
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GF164
20 µg  
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      Overview

      Replacement Information

      Key Spec Table

      SourcePurity
      Hela CellsProduct is endotoxin free (< 0.1ng/μg of protein (<1EU/μg) and greater than 95% pure by SDS-PAGE gel and HPLC analyses
      Description
      Catalogue NumberGF164
      DescriptionANG-1 Protein, Human Recombinant
      Alternate Names
      • ANG1
      • Angiopoietin1
      • Hepatic fibrinogen/angiopoietin-related protein
      • PPARG angiopoietin related protein
      • angiopoietin-like 4
      • angiopoietin-like 4 protein
      • angiopoietin-related protein 4
      Background InformationAngiopoietin1 (Ang1) and Angiopoietin2 (Ang2) are two closely related secreted ligands which bind with similar affinity to Tie2,
      a receptor tyrosine kinase with immunoglobulin and epidermal growth factor homology domains expressed primarily on endothelial cells and early hematopoietic cells. Tie2 and angiopoietins have been shown to play critical roles in embryogenic angiogenesis and in maintaining the integrity of the adult vasculature. Ang-1/Tie-2 signaling appears to be regulated by Angiopoietin-2 (Ang-2), a natural antagonist for Tie-2 that exerts its effects through an internal autocrine loop mechanism. In addition to suppressing endothelial cell activation by inhibiting the expression of adhesion and inflammatory molecules, Ang-1 enhances endothelial cell survival and capillary morphogenesis, and lessens capillary permeability. As such, Ang-1 has a potential to become an effective therapeutic agent for treating various endothelium disorders, including several severe human pulmonary diseases. Recombinant human ANG-1, derived from HeLa cells, is a C-terminal histidine tagged glycoprotein which migrates with an apparent molecular mass of 60.0 – 70.0 kDa by SDS-PAGE under reducing conditions. Sequencing analysis shows N-terminal sequences starting with Ser-20 and with Asp-70 of the 498 amino acid precursor protein.
      References
      Product Information
      PresentationProduct is filtered through a 0.2 micron filter before lyophilization.
      Quality LevelMQ100
      Applications
      ApplicationThe Ang-1 protein & Ang-2 protein are secreted ligands which bind with similar affinity to Tie2, a receptor tyrosine kinase with immunoglobulin & epidermal growth factor homology domains expressed on endothelial & early hematopoietic cells.
      Biological Information
      PurityProduct is endotoxin free (< 0.1ng/μg of protein (<1EU/μg) and greater than 95% pure by SDS-PAGE gel and HPLC analyses
      SourceHela Cells
      Cross ReactivityNone
      UniProt Number
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceBioactivity assay: Determined by its ability to induce adhesion of human umbilical vein endothelial cells (HUVEC).
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore at -20°C for up to 6 months from date of receipt.
      Packaging Information
      Material Size20 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      GF164 04053252691218

      Documentation

      ANG-1 Protein, Human Recombinant MSDS

      Title

      Safety Data Sheet (SDS) 

      ANG-1 Protein, Human Recombinant Certificates of Analysis

      TitleLot Number
      Recombinant Human -2556024 2556024
      Recombinant Human -2804758 2804758
      Recombinant Human ANG-1 - 2074788 2074788
      Recombinant Human ANG-1 - 3481381 3481381
      Recombinant Human ANG-1 - 3800036 3800036
      Recombinant Human ANG-1 - 4029331 4029331
      Recombinant Human ANG-1 - Q2007170 Q2007170
      Recombinant Human ANG-1 Recombinant Protein 2893646
      Recombinant Human ANG-1 Recombinant Protein 3121775

      Brochure

      Title
      New Products: Volume 3, 2012

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